Graduate Medical Education, University of Central Florida College of Medicine, Gainesville, FL, USA.
Internal Medicine Residency Program, HCA Florida North Florida Hospital, Gainesville, FL, USA.
Am J Case Rep. 2023 Jun 14;24:e939179. doi: 10.12659/AJCR.939179.
BACKGROUND Synchronous tumors occur when 2 separate primary tumors are diagnosed within 6 months. They can originate from the same site or different locations. For example, synchronous primary tumors of uterine and ovarian origin are a common type. Diagnosis can be challenging, however is critical to determine whether a patient has multiple primary tumors or a single tumor with metastasis to guide effective treatment. Compared with endometrial cancer that has spread to the ovary, synchronous primary tumors of the uterus and ovaries typically require less aggressive treatment. CASE REPORT A 45-year-old woman with nonspecific symptoms of headache and confusion had imaging studies that revealed a neoplasm in her brain, which was likely causing her symptoms. The masses were metastatic lesions, and the primary cancer was determined to be synchronous endometrial ovarian cancer (SEOC). She underwent bilateral frontal craniotomy for tumor resection and diagnostic tests. She had an exploratory laparotomy, total abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. She was stable during hospitalization but lost to follow-up after discharge. CONCLUSIONS Regular gynecologic examinations, including bimanual palpation of the ovaries during cervical cancer screenings, are essential for detecting cancer early and improving chances of recovery. This case also highlights the indolent growth and high risk of metastasis associated with SEOC. Although this type of cancer is rare, patients with it can be at increased risk of developing metastatic lesions in other parts of their bodies. To manage synchronous tumors effectively, a multidisciplinary approach and close collaboration between medical professionals are necessary to ensure best patient outcomes.
当在 6 个月内诊断出 2 个独立的原发性肿瘤时，就会发生同步肿瘤。它们可以源自同一部位或不同部位。例如，子宫和卵巢来源的同步原发性肿瘤是一种常见类型。然而，诊断具有挑战性，因为这对于确定患者是患有多个原发性肿瘤还是具有转移的单一肿瘤以指导有效治疗至关重要。与已经扩散到卵巢的子宫内膜癌相比，子宫和卵巢的同步原发性肿瘤通常需要较少的激进治疗。
一名 45 岁的女性出现头痛和意识模糊等非特异性症状，影像学研究显示她的大脑中有一个肿瘤，这可能是导致她症状的原因。这些肿块是转移性病变，原发性癌症被确定为同步子宫内膜卵巢癌（SEOC）。她接受了双侧额部开颅手术进行肿瘤切除和诊断性检查。她进行了剖腹探查术、全子宫切除术、双侧输卵管卵巢切除术和网膜切除术。她在住院期间稳定，但出院后失去了随访。
定期进行妇科检查，包括在宫颈癌筛查期间进行卵巢双合诊，对于早期发现癌症并提高康复机会至关重要。这个病例还强调了 SEOC 生长缓慢和转移风险高的特点。虽然这种类型的癌症很少见，但患有这种癌症的患者可能会增加身体其他部位发生转移性病变的风险。为了有效地管理同步肿瘤，需要采用多学科方法，并在医疗专业人员之间密切合作，以确保患者获得最佳结果。
