Department Cell Biology of the Skin, Cologne Excellence Cluster for Stress Responses in Ageing-associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, University of Cologne, Cologne, Germany.
J Cell Biol. 2023 Jul 3;222(7). doi: 10.1083/jcb.202305022. Epub 2023 Jun 14.
How adult stem cells signal in vivo over time to coordinate their fate and behavior across self-renewing tissues remains a challenging question. In this issue, Moore et al. (2023. J. Cell Biol.https://doi.org/10.1083/jcb.202302095) combine high-resolution live imaging in mice with machine learning tools to reveal temporally regulated tissue-scale patterns of Ca2+ signaling orchestrated by cycling basal stem cells of the skin epidermis.
成体干细胞如何在体内随时间发出信号，以协调自我更新组织中它们的命运和行为，这仍然是一个具有挑战性的问题。在本期杂志中，Moore 等人（2023. J. Cell Biol. https://doi.org/10.1083/jcb.202302095）结合小鼠高分辨率实时成像和机器学习工具，揭示了由皮肤表皮的循环基底干细胞协调的、具有时间调控的组织尺度钙信号的时空模式。
