Vietnam Colorectal Cancer and Polyps Research Program, Vinmec Healthcare System, Hanoi, Vietnam.
College of Health Sciences, VinUniversity (VinUni), Hanoi, Vietnam.
Cancer Epidemiol Biomarkers Prev. 2023 Sep 1;32(9):1160-1168. doi: 10.1158/1055-9965.EPI-23-0056.
Colorectal cancer is one of the leading cancers worldwide and in Vietnam. Adenomas are important precursors of colorectal cancer. Study on the association between sleep duration and development of colorectal adenoma (CRA) is limited, particularly among Vietnamese population.
We conducted an individually matched case-control study of 870 CRA cases and 870 controls in a large-scale colorectal screening program involving 103,542 individuals ages ≥40 years old in Hanoi, Vietnam. Sleep duration was categorized in three groups: short: ≤6 hours/day, normal: 7 to 8 hours/day, and long: >8 hours/day. Conditional logistic regression was used to evaluate the association between sleep duration and adenomas risk after controlling for potential confounders.
Overall, short-sleep duration was associated with increased risk of having CRA compared with normal duration [OR, 1.48; 95% confidence interval (CI), 1.12-1.97]. This pattern was present in both females (OR, 1.58; 95% CI, 1.14-2.18) and males (OR, 1.45; 95% CI, 1.08-1.93), with advanced adenomas (OR, 1.61; 95% CI, 1.09-2.38) and non-advanced adenomas (OR, 1.66; 95% CI, 1.19-2.32). Furthermore, the association between CRA development and short-sleep duration was more apparent among females who were nondrinker, nonobese, physically active, with proximal or both sided adenomas and with cardiometabolic disorder. Among males, the short-sleep duration was associated with CRA risk among never-smoking, cardiometabolic disorders, and obese.
Short-sleep duration was associated with increased prevalence of both advanced and non-advanced CRAs among Vietnamese population.
Findings from this study showed that maintaining an adequate sleep duration may have an important implication for colorectal adenoma prevention and control.
结直肠癌是全球和越南的主要癌症之一。腺瘤是结直肠癌的重要前体。关于睡眠时间与结直肠腺瘤（CRA）发展之间的关联的研究有限，特别是在越南人群中。
我们在越南河内的一项涉及 103542 名年龄≥40 岁的大规模结直肠筛查计划中，对 870 例 CRA 病例和 870 例对照进行了个体匹配的病例对照研究。睡眠时间分为三组：短：≤6 小时/天，正常：7 至 8 小时/天，长：>8 小时/天。在控制潜在混杂因素后，使用条件逻辑回归评估睡眠时间与腺瘤风险之间的关联。
总体而言，与正常持续时间相比，短睡眠时间与 CRA 的风险增加相关[比值比（OR），1.48；95%置信区间（CI），1.12-1.97]。这种模式在女性（OR，1.58；95%CI，1.14-2.18）和男性（OR，1.45；95%CI，1.08-1.93）中均存在，并且与高级腺瘤（OR，1.61；95%CI，1.09-2.38）和非高级腺瘤（OR，1.66；95%CI，1.19-2.32）相关。此外，在非饮酒、非肥胖、身体活跃、近端或双侧腺瘤和代谢紊乱的女性中，CRA 发展与短睡眠时间之间的关联更为明显。在男性中，短睡眠时间与从不吸烟、代谢紊乱和肥胖的 CRA 风险相关。
短睡眠时间与越南人群中高级和非高级 CRA 的患病率增加有关。
本研究结果表明，保持足够的睡眠时间可能对结直肠腺瘤的预防和控制具有重要意义。
