Huisjes H J, Hadders-Algra M, Touwen B C
Early Hum Dev. 1986 Jul;14(1):43-8. doi: 10.1016/0378-3782(86)90168-4.
Twenty-two children prenatally exposed to clonidine and no other hypotensive drugs were compared at a mean age of 6.3 +/- 1.6 years to a non-exposed control group, matched for degree of maternal hypertension, sex, birthweight and gestational age. There were no differences in head circumference, neurological findings, school performance and a number of behavioural characteristics except for a marginal excess of hyperactivity and an excess of sleep disturbances in the study group. It is questionable whether the differences represent a direct effect of clonidine on prenatal development but the dose-effect relationship and the fact that the same effects have been found in rats suggest that this may be so.
将22名产前接触可乐定且未接触其他降压药物的儿童，在平均年龄6.3±1.6岁时与未接触可乐定的对照组进行比较，对照组在母亲高血压程度、性别、出生体重和胎龄方面相匹配。除研究组中多动略有增加和睡眠障碍过多外，两组在头围、神经学检查结果、学业成绩和一些行为特征方面没有差异。这些差异是否代表可乐定对产前发育的直接影响尚存在疑问，但剂量效应关系以及在大鼠中发现了相同效应这一事实表明可能如此。
