Amiri Rezvan, Farrokhnia Mehrdad, Mousavi Mehdiabadi Fatemeh
Leishmaniasis Research Center Kerman University of Medical Sciences Kerman Iran.
Research Center of Tropical and Infectious Diseases Kerman University of Medical Sciences Kerman Iran.
Clin Case Rep. 2023 Jun 13;11(6):e7549. doi: 10.1002/ccr3.7549. eCollection 2023 Jun.
In this case of disseminated cutaneous leishmaniasis in our immunosuppressive patient who was a refractor to treatment with intra-lesion Glucantime® and systemic L-AmB, considering the good clinical response to oral miltefosine, this drug might be the best treatment option.
Diagnosis and treatment of leishmaniasis are challenging in immunosuppressed patients. Here, we report a 46-year-old male renal transplant recipient with disseminated cutaneous leishmaniasis presenting with multiple lesions on the face and upper extremities 15 years after transplant with a challenging course of treatment with meglumine antimoniate, liposomal amphotericin B, and miltefosine.
在我们这位免疫抑制患者的播散性皮肤利什曼病病例中,该患者对病灶内注射葡糖酸锑钠和全身使用脂质体两性霉素B治疗无效,考虑到口服米替福新有良好的临床反应,该药可能是最佳治疗选择。
利什曼病的诊断和治疗在免疫抑制患者中具有挑战性。在此,我们报告一名46岁男性肾移植受者,在移植15年后出现播散性皮肤利什曼病,面部和上肢有多处皮损,接受葡甲胺锑酸盐、脂质体两性霉素B和米替福新治疗的过程颇具挑战性。