Zylber-Katz E, Linder N, Granit L, Levy M
Eur J Clin Pharmacol. 1986;30(3):359-61. doi: 10.1007/BF00541545.
Breast milk and plasma levels of dipyrone metabolites in 8 mothers given a single oral dose of the drug were determined by HPLC. Four metabolites were demonstrated by the analytical method: 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA) and 4-acetylaminoantipyrine (AAA). A good correlation was found between the plasma and milk concentrations of the metabolites. The mean (+/- SD) milk to plasma concentration ratios were: MAA = 1.37 +/- 0.28, AA = 1.15 +/- 0.40, FAA = 1.03 +/- 0.09, AAA = 0.97 +/- 0.24. The disposition pattern of the dipyrone metabolites in milk was studied in two mothers. None of the metabolites was detectable 48 h after drug administration.
采用高效液相色谱法测定了8名单次口服该药物的母亲的母乳和血浆中安乃近代谢物的水平。该分析方法鉴定出4种代谢物：4-甲基氨基安替比林（MAA）、4-氨基安替比林（AA）、4-甲酰氨基安替比林（FAA）和4-乙酰氨基安替比林（AAA）。发现代谢物的血浆浓度与乳汁浓度之间具有良好的相关性。代谢物的平均（±标准差）乳汁与血浆浓度比为：MAA = 1.37 ± 0.28，AA = 1.15 ± 0.40，FAA = 1.03 ± 0.09，AAA = 0.97 ± 0.24。在两名母亲中研究了安乃近代谢物在乳汁中的分布模式。给药48小时后未检测到任何代谢物。
