Nivatti Jyotsana, Halder Sumita, Goel Ashish, Gupta Rachna, Wason Rhea
Department of Pharmacology, University College of Medical Sciences and GTB Hospital, New Delhi, India.
Department of Medicine, University College of Medical Sciences and GTB Hospital, New Delhi, India.
J Midlife Health. 2022 Oct-Dec;13(4):288-293. doi: 10.4103/jmh.jmh_146_22. Epub 2023 Apr 28.
Long term effects of COVID are not fully understood yet. The geriatric population has been badly affected. The impact of COVID-19 on the health-related quality of life after recovery and patient compliance is a matter of concern especially in the geriatric population where polypharmacy is often prevalent.
This study intended to observe the occurrence of polypharmacy (PP) among COVID-19 recovered older patients with multimorbidity and explore its association with health-related quality of life and compliance in these patients.
Total 90 patients, above 60 years of age having two or more co-morbidities and recovered from COVID-19 infection were included in this cross-sectional study. Number of pills taken daily by each patient was noted, to determine the occurrence of PP. WHO-QOL-BREF was used to assess the effect of PP on health-related quality of life (HRQOL). Medication adherence was measured using a self-reported questionnaire.
PP was found in 94.4% while hyper polypharmacy was found in 45.56% of patients. The overall mean score of HRQOL in patients with PP was 187.91 ± 32.98, indicating poor quality of life with PP ( value 0.0014) whereas the overall mean score of HRQOL in patients with hyper polypharmacy was 177.41 ± 26.11, showing poor quality of life with hyper polypharmacy ( value 0.0005). Increased number of pills corelated with poor quality of life ( =0.49). The medication adherence was found to be poor in patients who received mean number of pills 10.44 ± 2.62 whereas the adherence was good if the mean number of pills was 8.20 ± 2.63, ( value of 0.0001).
Polypharmacy is highly prevalent among COVID-19 recovered patients and is associated with poor quality of life as well as poor medication adherence.
新冠病毒的长期影响尚未完全明了。老年人群受到了严重影响。新冠病毒感染康复后对健康相关生活质量以及患者依从性的影响令人担忧，尤其是在经常存在多种药物联合使用情况的老年人群中。
本研究旨在观察新冠病毒感染康复的患有多种疾病的老年患者中多种药物联合使用（PP）的发生情况，并探讨其与这些患者健康相关生活质量和依从性的关联。
本横断面研究纳入了90名60岁以上、患有两种或更多合并症且从新冠病毒感染中康复的患者。记录每位患者每天服用的药丸数量，以确定多种药物联合使用的发生情况。采用世界卫生组织生活质量简表（WHO-QOL-BREF）评估多种药物联合使用对健康相关生活质量（HRQOL）的影响。使用自我报告问卷测量药物依从性。
94.4%的患者存在多种药物联合使用情况，45.56%的患者存在超多种药物联合使用情况。多种药物联合使用患者的健康相关生活质量总体平均得分为187.91±32.98，表明多种药物联合使用时生活质量较差（P值为0.0014）；而超多种药物联合使用患者的健康相关生活质量总体平均得分为177.41±26.11，表明超多种药物联合使用时生活质量较差（P值为0.0005）。药丸数量增加与生活质量差相关（r=0.49）。平均服用药丸数量为10.44±2.62的患者药物依从性较差，而平均服用药丸数量为8.20±2.63时依从性良好（P值为0.0001）。
多种药物联合使用在新冠病毒感染康复患者中非常普遍，并且与生活质量差以及药物依从性差相关。
