Talebi Saeedeh, Day Andrew S, Safarian Mahammad, Sayedi Seyed Javad, Jaafari Mahmood Reza, Abbasi Zahra, Barghchi Hanieh, Kianifar Hamid Reza
Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Department of Pediatrics University of Otago Christchurch New Zealand.
Food Sci Nutr. 2023 Mar 28;11(6):3348-3357. doi: 10.1002/fsn3.3323. eCollection 2023 Jun.
Inflammation may develop due to internal dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein or external factors in patients with cystic fibrosis (CF). This prospective randomized clinical trial aimed to ascertain the effects of nano-curcumin as an anti-inflammatory agent and a CFTR modulator on clinical and inflammatory markers in children with CF. Children with CF were randomly assigned to receive daily curcumin or a placebo for 3 months. The primary outcome measure was to evaluate inflammatory indices, nasopharyngeal swab analysis, and clinical assessments via spirometry, anthropometric measurements, and quality of life (QOL) analysis. Sixty children were included. Intra-group changes comparison showed that curcumin decreased the level of high-sensitivity C-reactive protein (hs-CRP) (median: -0.31 mg/L, IQR: -1.53 to 0.81; = .01) and fecal calprotectin level (-29 μg/g, -57.5 to 11.5; = .03), also increased the level of interleukin (IL)-10 (6.1 pg/mL, 4.5-9; = .01). Moreover, curcumin improved the overall QOL and the subscales of the questionnaire. Inter-group changes comparison depicted the number of colonies reduced by about 52% in the curcumin group and gained weight by about 16% ( > .05). Nano-curcumin seems to be considered as an effective nutritional supplement on hs-CRP, IL-10, fecal calprotectin levels, and improving QOL in patients with CF.
在囊性纤维化（CF）患者中，炎症可能由于囊性纤维化跨膜传导调节因子（CFTR）蛋白的内部功能障碍或外部因素而发生。这项前瞻性随机临床试验旨在确定纳米姜黄素作为一种抗炎剂和CFTR调节剂对CF儿童临床和炎症标志物的影响。CF儿童被随机分配，每天接受姜黄素或安慰剂治疗3个月。主要结局指标是通过肺活量测定、人体测量和生活质量（QOL）分析来评估炎症指标、鼻咽拭子分析和临床评估。纳入了60名儿童。组内变化比较显示，姜黄素降低了高敏C反应蛋白（hs-CRP）水平（中位数：-0.31mg/L，四分位距：-1.53至0.81；P =.01）和粪便钙卫蛋白水平（-29μg/g，-57.至11.5；P =.03），还提高了白细胞介素（IL）-10水平（6.1pg/mL，4.5 - 9；P =.01）。此外，姜黄素改善了总体QOL和问卷的各个子量表。组间变化比较显示，姜黄素组的菌落数量减少了约52%，体重增加了约16%（P＞.05）。纳米姜黄素似乎可被视为一种对CF患者的hs-CRP、IL-10、粪便钙卫蛋白水平以及改善QOL有效的营养补充剂。
