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The causal relationship between immune cells and knee osteoarthritis: Mendelian randomization study.免疫细胞与膝关节骨关节炎之间的因果关系：孟德尔随机化研究
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Autoantibodies cause nociceptive sensitization in a mouse model of degenerative osteoarthritis.自身抗体在退行性骨关节炎小鼠模型中引起伤害性致敏。
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Unravelling the ties that bind: The intersection of obesity, osteoarthritis, and inflammatory pathways with emphasis on glucagon-like peptide-1 agonists.解开关联之纽带：肥胖、骨关节炎与炎症通路的交叉点，重点关注胰高血糖素样肽-1激动剂
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Lymphatic vessels: roles and potential therapeutic intervention in rheumatoid arthritis and osteoarthritis.淋巴管：类风湿关节炎和骨关节炎中的作用和潜在治疗干预。
Theranostics. 2024 Jan 1;14(1):265-282. doi: 10.7150/thno.90940. eCollection 2024.

本文引用的文献

1
B-cell capacity for expansion and differentiation into plasma cells are altered in osteoarthritis.骨关节炎中 B 细胞的扩增和分化为浆细胞的能力发生改变。
Osteoarthritis Cartilage. 2023 Sep;31(9):1176-1188. doi: 10.1016/j.joca.2023.03.017. Epub 2023 Jun 7.
2
Insights into B-cell ontogeny inferred from human immunology.从人类免疫学角度洞察 B 细胞发生。
Eur J Immunol. 2023 Jun;53(6):e2250116. doi: 10.1002/eji.202250116. Epub 2023 Apr 5.
3
NK-cell exhaustion, B-cell exhaustion and T-cell exhaustion-the differences and similarities.NK 细胞耗竭、B 细胞耗竭和 T 细胞耗竭——异同点。
Immunology. 2022 Jun;166(2):155-168. doi: 10.1111/imm.13464. Epub 2022 Mar 30.
4
Synovial inflammation in osteoarthritis progression.骨关节炎进展中的滑膜炎症。
Nat Rev Rheumatol. 2022 May;18(5):258-275. doi: 10.1038/s41584-022-00749-9. Epub 2022 Feb 14.
5
Auto-antibodies to post-translationally modified proteins in osteoarthritis.骨关节炎中翻译后修饰蛋白的自身抗体。
Osteoarthritis Cartilage. 2021 Jun;29(6):924-933. doi: 10.1016/j.joca.2021.03.008. Epub 2021 Mar 20.
6
Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis.促炎T细胞极化在早期膝骨关节炎患者中已经存在。
Arthritis Res Ther. 2021 Jan 22;23(1):37. doi: 10.1186/s13075-020-02410-w.
7
Association between Bone marrow lesions & synovitis and symptoms in symptomatic knee osteoarthritis.症状性膝关节骨关节炎中骨髓病变和滑膜炎与症状的相关性。
Osteoarthritis Cartilage. 2020 Mar;28(3):316-323. doi: 10.1016/j.joca.2019.12.002. Epub 2019 Dec 23.
8
IgMCD27 B cells possessed regulatory function and represented the main source of B cell-derived IL-10 in the synovial fluid of osteoarthritis patients.IgMCD27 B细胞具有调节功能，是骨关节炎患者滑液中B细胞源性白细胞介素-10的主要来源。
Hum Immunol. 2019 Apr;80(4):263-269. doi: 10.1016/j.humimm.2019.02.007. Epub 2019 Feb 12.
9
Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.条件性巨噬细胞耗竭增加炎症反应，并不抑制肥胖巨噬细胞 Fas 诱导凋亡转基因小鼠骨关节炎的发展。
Arthritis Rheumatol. 2017 Sep;69(9):1772-1783. doi: 10.1002/art.40161. Epub 2017 Aug 8.
10
Synovitis and the risk of knee osteoarthritis: the MOST Study.滑膜炎与膝关节骨关节炎风险：MOST研究
Osteoarthritis Cartilage. 2016 Mar;24(3):458-64. doi: 10.1016/j.joca.2015.09.013. Epub 2015 Sep 30.

B cells in osteoarthritis: simply a sign or a target for therapy?

作者信息

Burt Kevin G, Scanzello Carla R

机构信息

University of Pennsylvania Perelman School of Medicine, Department of Orthopaedic Surgery, Philadelphia, PA, USA; Corporal Michael J. Crescenz VA Medical Center, Translational Musculoskeletal Research Center, Philadelphia, PA, USA.

Corporal Michael J. Crescenz VA Medical Center, Translational Musculoskeletal Research Center, Philadelphia, PA, USA; University of Pennsylvania Perelman School of Medicine, Division of Rheumatology, Philadelphia, PA, USA.

出版信息

Osteoarthritis Cartilage. 2023 Sep;31(9):1148-1151. doi: 10.1016/j.joca.2023.06.002. Epub 2023 Jun 14.

DOI:10.1016/j.joca.2023.06.002
PMID:37328048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10680778/
Abstract
摘要