Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Department of Medicine, Hadassah Medical Center, Jerusalem, Israel.
Transpl Int. 2023 Jun 2;36:11176. doi: 10.3389/ti.2023.11176. eCollection 2023.
Adropin is a peptide that was suggested to have a role in cirrhosis. The present study aimed to determine the ability to use serum adropin levels to improve their prediction accuracy as an adjunct to the current scores. In a single-center, proof-of-concept study, serum adropin levels were determined in thirty-three cirrhotic patients. The data were analyzed in correlation with Child-Pugh and MELD-Na scores, laboratory parameters, and mortality. Adropin levels were higher among cirrhotic patients that died within 180 days (1,325.7 ng/dL vs. 870.3 ng/dL, = 0.024) and inversely correlated to the time until death ( = 0.74). The correlation of adropin serum levels with mortality was better than MELD or Child-Pough scores ( = 0.32 and 0.38, respectively). Higher adropin levels correlated with creatinine ( = 0.79. < 0.01). Patients with diabetes mellitus and cardiovascular diseases had elevated adropin levels. Integrating adropin levels with the Child-Pugh and MELD scores improved their correlation with the time of death (correlation coefficient: 0.91 vs. 0.38 and 0.67 vs. 0.32). The data of this feasibility study suggest that combining serum adropin with the Child-Pugh score and MELD-Na score improves the prediction of mortality in cirrhosis and can serve as a measure for assessing kidney dysfunction in these patients.
瘦素是一种被认为在肝硬化中起作用的肽。本研究旨在确定使用血清瘦素水平来提高其预测准确性的能力，作为对当前评分的补充。在一项单中心概念验证研究中，测定了 33 例肝硬化患者的血清瘦素水平。将数据与 Child-Pugh 和 MELD-Na 评分、实验室参数和死亡率进行了相关性分析。在 180 天内死亡的肝硬化患者的瘦素水平较高（1325.7ng/dL 与 870.3ng/dL， = 0.024），与死亡时间呈负相关（ = 0.74）。瘦素血清水平与死亡率的相关性优于 MELD 或 Child-Pugh 评分（ = 0.32 和 0.38）。较高的瘦素水平与肌酐呈正相关（ = 0.79， < 0.01）。患有糖尿病和心血管疾病的患者瘦素水平升高。将瘦素水平与 Child-Pugh 和 MELD 评分相结合，提高了它们与死亡时间的相关性（相关系数：0.91 与 0.38 和 0.67 与 0.32）。这项可行性研究的数据表明，将血清瘦素与 Child-Pugh 评分和 MELD-Na 评分相结合，可提高对肝硬化患者死亡率的预测能力，并可作为评估这些患者肾功能的一种手段。
