大鼠嗅鞘细胞的分离及其在创伤性脊髓囊肿治疗中的应用。
Isolation of Rat Olfactory Ensheathing Cells and Their Use in the Therapy of Posttraumatic Cysts of the Spinal Cord.
作者信息
Stepanova O V, Voronova А D, Chadin A V, Valikhov M P, Abakumov M A, Reshetov I V, Chekhonin V P
机构信息
Department of Fundamental and Applied Neurobiology, V. P. Serbsky National Medical Research Centre for Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
Department of Medical Nanobiotechnologies, Medico-Biological Faculty, N. I. Pirogov National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2018 May;165(1):132-135. doi: 10.1007/s10517-018-4114-x. Epub 2018 May 24.
We evaluated the efficacy of rat olfactory ensheathing cells in the therapy of experimental cysts of the spinal cord. Improvement of the motor function of the hind limbs after transplantation of the olfactory ensheathing cells into the posttraumatic spinal cord cysts rats was found. We also determined the required number of cells for transplantation and demonstrated a neuroprotective effect of this dosage. For further clinical studies, autologous tissue-specific cell preparation of olfactory ensheathing cells has to be created. Cell therapy in combination surgical and pharmacological treatment will substantially improve the quality of life of patients with posttraumatic spinal cord cysts.
我们评估了大鼠嗅鞘细胞在治疗实验性脊髓囊肿中的疗效。将嗅鞘细胞移植到创伤后脊髓囊肿大鼠体内后，发现后肢运动功能有所改善。我们还确定了移植所需的细胞数量，并证明了该剂量具有神经保护作用。为了进一步开展临床研究，必须制备嗅鞘细胞的自体组织特异性细胞制剂。细胞治疗与手术和药物治疗相结合将显著改善创伤后脊髓囊肿患者的生活质量。
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