Antiproliferative assay of suma or Brazilian ginseng () methanolic extract on HCT116 and 4T1 cancer cell lines, toxicity on larvae, and antibacterial activity.

is a medicinal plant used in folk medicine and a subject of commercial interest. The cytotoxicity effects from root extracts on cancerous and normal cells were assessed by the MTT method, and toxicity was evaluated on . The inhibition of the proliferation of bacteria and MIC values were examined by the disc diffusion and the broth microdilution method, respectively. Human colon cancer HCT116 and mouse breast tumour model 4T1 cells treated with methanolic extract showed a significant decrease in viability of cells with IC: 272.6 and 88.5 µg/mL at 72h, respectively. The methanolic extract of showed moderate toxicity against (LC 589.4 µg/mL). In antimicrobial activity, the methanolic extract showed the highest inhibitory function against and (17.5 and 16 mm) with MICs of 500 µg/mL. The results confirmed the potential of plant roots as cytotoxic agents.