From the Family Medicine Department, University of Ilorin Teaching Hospital.
Family Medicine Department, General Hospital Ilorin, Ilorin, Kwara State, Nigeria.
Menopause. 2023 Aug 1;30(8):849-854. doi: 10.1097/GME.0000000000002207. Epub 2023 Jun 20.
There are limited data on the associated factors of circulating endogenous estradiol among Nigerian postmenopausal women. The main objective of this study is to assess the relationship between serum estradiol levels and some menstrual, clinical, and sociodemographic factors in postmenopausal women attending a family medicine clinic in Nigeria.
This was a hospital-based cross-sectional study involving 372 postmenopausal women. Sociodemographic, menstrual, and clinical data of the participants were collected, and their serum estradiol concentrations were assayed. The collected data were analyzed using IBM SPSS version 21 statistical software. A χ2 test of association and logistic regression analysis were done to identify significant correlates of serum estradiol concentration among the participants.
The mean ages at menarche and menopause among the participants were 15.6 and 48.1 years respectively. Approximately half of them (51.1%) were receiving chronic medical care for systemic hypertension and/or diabetes. The mean estradiol concentration of the participants in the study was 20.69 pg/mL. The participants' marital status and clinical presentation pattern (chronic vs others) were found to have statistically significant associations with their serum estradiol concentration; P = 0.048 and P = 0.001, respectively. Logistic regression analysis revealed that only the clinical presentation pattern had a significant relationship with serum estradiol concentration among the participants ( P = 0.002).
Of all the studied factors, the only significant correlate of low serum estradiol concentration found in this study was chronic medical care presentation for hypertension and/or diabetes.
关于尼日利亚绝经后女性循环内源性雌二醇的相关因素，数据有限。本研究的主要目的是评估在尼日利亚一家家庭医学诊所就诊的绝经后妇女的雌二醇水平与一些月经、临床和社会人口统计学因素之间的关系。
这是一项基于医院的横断面研究，共纳入 372 名绝经后妇女。收集参与者的社会人口统计学、月经和临床数据，并检测其血清雌二醇浓度。使用 IBM SPSS 版本 21 统计软件对收集的数据进行分析。采用 χ2 检验和逻辑回归分析来确定参与者血清雌二醇浓度的显著相关因素。
参与者的初潮年龄和绝经年龄分别为 15.6 岁和 48.1 岁。其中约一半（51.1%）正在接受慢性医疗护理，用于治疗系统性高血压和/或糖尿病。研究中参与者的平均雌二醇浓度为 20.69pg/mL。参与者的婚姻状况和临床表现模式（慢性与其他）与他们的血清雌二醇浓度有统计学显著关联；P=0.048 和 P=0.001。逻辑回归分析显示，只有临床表现模式与参与者的血清雌二醇浓度有显著关系（P=0.002）。
在所研究的所有因素中，本研究中发现的唯一与低血清雌二醇浓度显著相关的因素是高血压和/或糖尿病的慢性医疗护理表现。
