Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, No. 98, Xiwu Road, Xincheng District, Xi'an, 710004, China.
Department of Periodontology, College of Stomatology, Xi'an Jiaotong University, No. 98, Xiwu Road, Xincheng District, Xi'an, 710004, China.
Clin Oral Investig. 2023 Aug;27(8):4809-4816. doi: 10.1007/s00784-023-05111-1. Epub 2023 Jun 20.
The aim of this study is to explore the association between serum human epididymal protein (HE4) levels and poor periodontal health.
Data used in our study from the National Health and Nutrition Examination Survey (NHANES) 2001-2002 and Gene Expression Omnibus database (GSE10334 and GSE16134). Periodontitis category was defined by the 2017 classification scheme based on clinical periodontal parameters. Univariate and multivariate logistic regression analyses were used to explore the relationship between serum HE4 levels and the risk of periodontitis. GSEA analysis was performed to investigate the function of HE4.
A total of 1715 adult women over the age of 30 were included in our study. Compared with the lowest tertile, individuals in the highest tertile of HE4 levels were more likely to be Stage III/IV periodontitis (OR = 2.35, 95% CI: 1.35-4.21). The association was still significant in populations who were less than 60 years old, non-Hispanic white, high school graduate, 1.3 < PI ≤ 3.5, non-smoker, current smoker, non-obese, obese, and who had not diabetes mellitus or had not hypertension. In addition, HE4 expression was upregulated in diseased gingival tissues and involved in cell proliferation and immunity.
Serum HE4 is positively associated with poor periodontal health in adult women.
Patients with high serum HE4 levels are more likely to have Stage III/IV periodontitis. HE4 has the potential to be used as a biomarker to predict the severity of periodontitis.
本研究旨在探讨血清人附睾蛋白（HE4）水平与牙周健康不良之间的关联。
我们的研究数据来自国家健康和营养检查调查（NHANES）2001-2002 年和基因表达综合数据库（GSE10334 和 GSE16134）。牙周炎类别根据基于临床牙周参数的 2017 分类方案定义。采用单变量和多变量逻辑回归分析来探讨血清 HE4 水平与牙周炎风险之间的关系。进行 GSEA 分析以研究 HE4 的功能。
本研究共纳入了 1715 名年龄在 30 岁以上的成年女性。与 HE4 水平最低三分位相比，HE4 水平最高三分位的个体更有可能患有牙周炎 III/IV 期（OR=2.35，95%CI：1.35-4.21）。在年龄小于 60 岁、非西班牙裔白人、高中及以上学历、1.3<PI≤3.5、不吸烟者、现吸烟者、非肥胖、肥胖、无糖尿病或无高血压的人群中，这种关联仍然显著。此外，HE4 表达在患病的牙龈组织中上调，并参与细胞增殖和免疫。
血清 HE4 与成年女性牙周健康不良呈正相关。
血清 HE4 水平较高的患者更有可能患有牙周炎 III/IV 期。HE4 有可能成为预测牙周炎严重程度的生物标志物。
