College of Materials Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 10029, China.
Department of Nuclear Medicine, Peking University First Hospital, Beijing, 100034, China.
J Nanobiotechnology. 2023 Jun 21;21(1):197. doi: 10.1186/s12951-023-01943-x.
Malignant tumors have been one of the major reasons for deaths worldwide. Timely and accurate diagnosis as well as effective intervention of tumors play an essential role in the survival of patients. Genomic instability is the important foundation and feature of cancer, hence, in vivo oncogene imaging based on novel probes provides a valuable tool for the diagnosis of cancer at early-stage. However, the in vivo oncogene imaging is confronted with great challenge, due to the extremely low copies of oncogene in tumor cells. By combining with various novel activatable probes, the molecular imaging technologies provide a feasible approach to visualize oncogene in situ, and realize accurate treatment of tumor. This review aims to declare the design of nanoprobes responded to tumor associated DNA or RNA, and summarize their applications in detection and bioimaging for tumors. The significant challenges and prospective of oncogene-targeting nanoprobes towards tumors diagnosis are revealed as well.
恶性肿瘤一直是全球死亡的主要原因之一。肿瘤的及时准确诊断和有效干预对患者的生存至关重要。基因组不稳定性是癌症的重要基础和特征，因此，基于新型探针的体内癌基因成像为早期癌症的诊断提供了有价值的工具。然而，由于肿瘤细胞中癌基因的拷贝数极低，体内癌基因成像面临着巨大的挑战。通过与各种新型的可激活探针相结合，分子成像技术为原位可视化癌基因提供了一种可行的方法，并实现了肿瘤的精确治疗。本综述旨在阐述针对与肿瘤相关的 DNA 或 RNA 的纳米探针的设计，并总结它们在肿瘤检测和生物成像中的应用。还揭示了针对肿瘤诊断的癌基因靶向纳米探针的重大挑战和前景。
