Key Laboratory of Colloid, Interface and Chemical Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhong Guan Cun, Beijing, 100190, China.
School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Adv Healthc Mater. 2018 Oct;7(20):e1800391. doi: 10.1002/adhm.201800391. Epub 2018 Jul 12.
Physiological parameters in tumor microenvironments, including hypoxia, low extracellular pH, enzymes, reducing conditions, and so on, are closely associated with the proliferation, angiogenesis, invasion, and metastasis of cancer, and impact the therapeutic administrations. Therefore, monitoring the tumor microenvironment is significant for diagnosing tumors, predicting the invasion potential, evaluating therapeutic efficacy, planning the treatment, and cancer prognostics. Noninvasive molecular imaging technologies combined with novel "smart" nanoparticle-based activatable probes provide a feasible approach to visualize tumor-associated microenvironment factors. This review summarizes recent achievements in the designs of "smart" molecular imaging nanoprobes responding to the tumor microenvironment-related features, and highlights the state of the art in tumor heterogeneity imaging.
肿瘤微环境中的生理参数，包括缺氧、低细胞外 pH 值、酶、还原条件等，与癌症的增殖、血管生成、侵袭和转移密切相关，并影响治疗管理。因此，监测肿瘤微环境对于诊断肿瘤、预测侵袭潜力、评估治疗效果、规划治疗和癌症预后都具有重要意义。将无创分子成像技术与新型“智能”基于纳米颗粒的可激活探针相结合，为可视化与肿瘤相关的微环境因素提供了一种可行的方法。本综述总结了针对肿瘤微环境相关特征的“智能”分子成像纳米探针设计的最新进展，并强调了肿瘤异质性成像的最新技术水平。
