红细胞放射性标记：未受损及热损伤细胞中铬、锝和铟的体外比较
Erythrocyte radiolabelling: in vitro comparison of chromium, technetium, and indium in undamaged and heat damaged cells.
作者信息
Peters A M, Osman S, Reavy H J, Chambers B, Deenmamode M, Lewis S M
出版信息
J Clin Pathol. 1986 Jul;39(7):717-21. doi: 10.1136/jcp.39.7.717.
The stability of the commonly used red cell radio labels chromium-51, indium-(111 or 113m), and technetium-99m, within intact red cells and stroma and their distribution within the cell were compared in undamaged and heat damaged red cells in relation to the clinical use of heat damaged cells in the assessment of splenic function. Chromium-51 labelled haemoglobin both in undamaged and heat damaged cells; indium predominantly labelled haemoglobin in undamaged cells but labelled stroma in heat damaged cells, even when the cells were labelled before heating; technetium-99m predominantly labelled haemoglobin in undamaged cells but only labelled stroma in heat damaged cells if these were heated before labelling. Indium was more firmly bound by stroma prepared from heat damaged cells, and technetium-99m showed a high rate of elution both from cells and stroma, although this rate was lower for heat damaged cells.
就热损伤细胞在脾功能评估中的临床应用而言，比较了常用红细胞放射性标记物铬 - 51、铟 - （111或113m）和锝 - 99m在完整红细胞和基质中的稳定性，以及它们在未受损和热损伤红细胞内的分布情况。铬 - 51在未受损和热损伤细胞中均标记血红蛋白；铟在未受损细胞中主要标记血红蛋白，但在热损伤细胞中标记基质，即使细胞在加热前已标记；锝 - 99m在未受损细胞中主要标记血红蛋白，但如果热损伤细胞在标记前加热，则仅标记基质。铟与热损伤细胞制备的基质结合更牢固，锝 - 99m从细胞和基质中的洗脱率都很高，不过热损伤细胞的洗脱率较低。
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