School of Food and Health, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China.
NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No. 2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China.
J Agric Food Chem. 2023 Jul 5;71(26):10169-10177. doi: 10.1021/acs.jafc.3c02512. Epub 2023 Jun 21.
This study presents the first nationwide study on the chronic health risks of chlorothalonil and its metabolite (4-OH-chlorothalonil) for Chinese adults and breastfed infants via dietary intake. The determination of chlorothalonil and 4-OH-chlorothalonil in dietary samples was accomplished by cold-induced liquid-liquid extraction using liquid chromatography─high-resolution mass spectrometry. Chlorothalonil and 4-OH-chlorothalonil were detected in 43.1 and 46.1% of total dietary samples, respectively, while only 4-OH-chlorothalonil was detected in 100% of breast milk samples. Chlorothalonil and 4-OH-chlorothalonil residues in dietary samples of Northwest China and Shandong regions were higher in comparison to those of other regions. No correlation between 4-OH-chlorothalonil residues in breast milk and adult daily dietary intake to total chlorothalonil indicates the presence of other exposure routes besides dietary exposure. Furthermore, a residue analysis of 4-OH-chlorothalonil in breast milk between urban and rural areas in all sampling locales showed no statistical difference ( > 0.05). The findings of this study reveal that the chronic health risks caused by dietary exposure to chlorothalonil and 4-OH-chlorothalonil are low for Chinese adults and breastfed infants.
本研究通过膳食摄入，首次针对中国成年人和哺乳期婴儿，开展了关于百菌清及其代谢物（4-羟基百菌清）的慢性健康风险的全国性研究。通过使用液相色谱-高分辨质谱法进行冷诱导液-液萃取，对膳食样本中的百菌清和 4-羟基百菌清进行了测定。结果表明，在所有膳食样本中，分别有 43.1%和 46.1%检测到百菌清和 4-羟基百菌清，而在所有母乳样本中均检测到 4-羟基百菌清。与其他地区相比，中国西北地区和山东省的膳食样本中百菌清和 4-羟基百菌清的残留量更高。母乳中 4-羟基百菌清残留量与成年人每日膳食摄入量与总百菌清之间无相关性，表明除膳食暴露外，还存在其他暴露途径。此外，对所有采样点的城乡地区母乳中 4-羟基百菌清的残留分析显示，差异无统计学意义（>0.05）。本研究结果表明，对于中国成年人和哺乳期婴儿而言，通过膳食摄入百菌清和 4-羟基百菌清造成的慢性健康风险较低。
