Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
Sci Rep. 2023 Dec 19;13(1):22569. doi: 10.1038/s41598-023-50068-6.
We investigated the difference in optical coherence tomography angiography characteristics between the patients with compressive optic neuropathy (CON, n = 26) and glaucomatous optic neuropathy (GON, n = 26), who were matched for the severity of visual field defect. The peripapillary retinal nerve fiber layer (pRNFL) thickness in the nasal and temporal sectors was thinner in the CON group, whereas the inferior pRNFL thickness was thinner in the GON group. Accordingly, the CON group had lower peripapillary vessel density (pVD) in the nasal and temporal sectors, and the GON group in the inferior sector. In the macular area, the CON group had a thinner macular ganglion cell-inner plexiform layer in the superior and nasal sectors, whereas the GON group in the inferior sector. However, the CON group did not have a lower macular VD than the GON group in any sector, whereas the GON group exhibited lower superficial capillary plexus VD in the superior, inferior, and temporal sectors. Comparison of the structure-vasculature correlation revealed a significant difference in the nasal and temporal peripapillary areas and superior and nasal macular sectors; a decrease in VD was greater in the GON group than in the CON group when the comparable structural change occurred.
我们研究了压迫性视神经病变(CON,n=26)和青光眼视神经病变(GON,n=26)患者之间的光学相干断层扫描血管造影特征差异,这些患者的视野缺损严重程度相匹配。CON 组的鼻侧和颞侧视盘周围视网膜神经纤维层(pRNFL)厚度较薄,而 GON 组的下方 pRNFL 厚度较薄。因此,CON 组鼻侧和颞侧视盘周围血管密度(pVD)较低,而 GON 组下方 pVD 较低。在黄斑区,CON 组的上侧和鼻侧黄斑神经节细胞-内丛状层较薄,而 GON 组的下侧黄斑神经节细胞-内丛状层较薄。然而,与 GON 组相比,CON 组在任何区域的黄斑血管密度都没有降低,而 GON 组在上侧、下侧和颞侧区域的浅层毛细血管丛血管密度较低。结构-血管相关性比较显示,鼻侧和颞侧视盘周围区域以及上侧和鼻侧黄斑区域存在显著差异;当发生可比的结构变化时,GON 组的血管密度下降幅度大于 CON 组。