Suppr超能文献

2021 年中国台湾地区人感染猪源甲型流感病毒 A(H1N2)v 病例。

Human infection with a reassortant swine-origin influenza A(H1N2)v virus in Taiwan, 2021.

机构信息

Center for Diagnostics and Vaccine Development, Centers for Disease Control, No. 161, Kun-Yang Street, Taipei, 11561, Taiwan, ROC.

Department of Laboratory Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC.

出版信息

Virol J. 2022 Apr 7;19(1):63. doi: 10.1186/s12985-022-01794-2.

Abstract

BACKGROUND

Influenza A virus infections occur in different species, causing mild-to-severe symptoms that lead to a heavy disease burden. H1N1, H1N2 and H3N2 are major subtypes of swine influenza A viruses in pigs and occasionally infect humans.

METHODS

A case infected by novel influenza virus was found through laboratory surveillance system for influenza viruses. Clinical specimens were tested by virus culture and/or real-time RT-PCR. The virus was identified and characterized by gene sequencing and phylogenetic analysis.

RESULTS

In 2021, for the first time in Taiwan, an influenza A(H1N2)v virus was isolated from a 5-year old girl who was suffering from fever, runny nose and cough. The isolated virus was designated A/Taiwan/1/2021(H1N2)v. Full-genome sequencing and phylogenetic analyses revealed that A/Taiwan/1/2021(H1N2)v is a novel reassortant virus containing hemagglutinin (HA) and neuraminidase (NA) gene segments derived from swine influenza A(H1N2) viruses that may have been circulating in Taiwan for decades, and the other 6 internal genes (PB2, PB2, PA, NP, M and NS) are from human A(H1N1)pdm09 viruses.

CONCLUSION

Notably, the HA and NA genes of A/Taiwan/1/2021(H1N2)v separately belong to specific clades that are unique for Taiwanese swine and were proposed to be introduced from humans in different time periods. Bidirectional transmission between humans and swine contributes to influenza virus diversity and poses the next pandemic threat.

摘要

背景

甲型流感病毒在不同物种中引发感染,导致从轻症到重症的各种症状,从而造成沉重的疾病负担。H1N1、H1N2 和 H3N2 是猪流感 A 病毒的主要亚型,偶尔会感染人类。

方法

通过流感病毒实验室监测系统发现了一例新型流感病毒感染病例。通过病毒培养和/或实时 RT-PCR 检测临床标本。通过基因测序和系统发育分析对病毒进行鉴定和特征分析。

结果

2021 年,在台湾,首次从一名 5 岁女孩身上分离出甲型流感 A(H1N2)v 病毒,该女孩患有发热、流鼻涕和咳嗽。分离出的病毒被命名为 A/Taiwan/1/2021(H1N2)v。全基因组测序和系统发育分析显示,A/Taiwan/1/2021(H1N2)v 是一种新型重配病毒,含有血凝素 (HA) 和神经氨酸酶 (NA) 基因片段,源自可能在台湾流行数十年的猪流感 A(H1N2)病毒,其他 6 个内部基因(PB2、PB1、PA、NP、M 和 NS)来自人类 A(H1N1)pdm09 病毒。

结论

值得注意的是,A/Taiwan/1/2021(H1N2)v 的 HA 和 NA 基因分别属于特定的分支,这些分支在台湾的猪中是独特的,据推测是在不同时期从人类引入的。人类和猪之间的双向传播促进了流感病毒的多样性,并构成了下一次大流行的威胁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2643/8991675/f2b83df9023b/12985_2022_1794_Fig1_HTML.jpg

相似文献

1
Human infection with a reassortant swine-origin influenza A(H1N2)v virus in Taiwan, 2021.
Virol J. 2022 Apr 7;19(1):63. doi: 10.1186/s12985-022-01794-2.
2
Novel H1N2 swine influenza reassortant strain in pigs derived from the pandemic H1N1/2009 virus.
Vet Microbiol. 2011 May 5;149(3-4):472-7. doi: 10.1016/j.vetmic.2010.12.011. Epub 2010 Dec 14.
6
Reassortant swine influenza viruses isolated in Japan contain genes from pandemic A(H1N1) 2009.
Microbiol Immunol. 2014 Jun;58(6):327-41. doi: 10.1111/1348-0421.12152.
8
Complete genome sequence of a novel influenza A H1N2 virus circulating in swine from Central Bajio region, Mexico.
Transbound Emerg Dis. 2017 Dec;64(6):2083-2092. doi: 10.1111/tbed.12620. Epub 2017 Feb 8.
9
10
Identification of swine H1N2/pandemic H1N1 reassortant influenza virus in pigs, United States.
Vet Microbiol. 2012 Jul 6;158(1-2):60-8. doi: 10.1016/j.vetmic.2012.02.014. Epub 2012 Feb 17.

引用本文的文献

2
Single-cell analysis of nasal epithelial cell development in domestic pigs.
Vet Res. 2024 Oct 30;55(1):140. doi: 10.1186/s13567-024-01403-w.
4
Detection of a reassortant swine H1N2 influenza A virus from pigs in Hong Kong.
Virol Sin. 2024 Apr;39(2):343-346. doi: 10.1016/j.virs.2024.01.009. Epub 2024 Feb 1.
5
Species comparison: human and minipig PBMC reactivity under the influence of immunomodulating compounds .
Front Immunol. 2024 Jan 9;14:1327776. doi: 10.3389/fimmu.2023.1327776. eCollection 2023.
6
Long-Term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam.
Emerg Infect Dis. 2023 Jul;29(7):1397-1406. doi: 10.3201/eid2907.230165.
7
A recent outbreak of human H1N2 infection: correspondence.
Int J Surg. 2023 Mar 1;109(3):604-605. doi: 10.1097/JS9.0000000000000185.

本文引用的文献

2
Prevalent Eurasian avian-like H1N1 swine influenza virus with 2009 pandemic viral genes facilitating human infection.
Proc Natl Acad Sci U S A. 2020 Jul 21;117(29):17204-17210. doi: 10.1073/pnas.1921186117. Epub 2020 Jun 29.
3
4
Human infection with a novel reassortant Eurasian-avian lineage swine H1N1 virus in northern China.
Emerg Microbes Infect. 2019;8(1):1535-1545. doi: 10.1080/22221751.2019.1679611.
5
Locally Acquired Human Infection with Swine-Origin Influenza A(H3N2) Variant Virus, Australia, 2018.
Emerg Infect Dis. 2020 Jan;26(1):143-147. doi: 10.3201/eid2601.191144. Epub 2020 Jan 17.
6
Bidirectional Human-Swine Transmission of Seasonal Influenza A(H1N1)pdm09 Virus in Pig Herd, France, 2018.
Emerg Infect Dis. 2019 Oct;25(10):1940-1943. doi: 10.3201/eid2510.190068.
7
Seasonal dynamics of influenza viruses and age distribution of infected individuals across nine seasons covering 2009-2018 in Taiwan.
J Formos Med Assoc. 2020 Apr;119(4):850-860. doi: 10.1016/j.jfma.2019.08.030. Epub 2019 Sep 11.
8
A human infection with a novel reassortant H3N2 swine virus in China.
J Infect. 2019 Aug;79(2):174-187. doi: 10.1016/j.jinf.2019.04.015. Epub 2019 May 1.
9

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验