帕金森病患者在疾病的开期和关期的运动及认知表现。
Motor and cognitive performances of parkinsonian patients in the on and off phases of the disease.
作者信息
Girotti F, Carella F, Grassi M P, Soliveri P, Marano R, Caraceni T
出版信息
J Neurol Neurosurg Psychiatry. 1986 Jun;49(6):657-60. doi: 10.1136/jnnp.49.6.657.
Abstract
Twenty-one Parkinsonian patients were tested in on and off phases during chronic levodopa therapy for cognitive function, affective status, and evaluation of motor performance with reaction and movement times. A worsening of mood was observed from the on to the off phase. No variation in cognitive performance was observed from the on to the off phase in spite of evident motor changes. Mood changes during on-off variations may reflect involvement of mesocortical and mesolimbic dopaminergic systems.
摘要
21名帕金森病患者在长期左旋多巴治疗期间的“开”期和“关”期接受了认知功能、情感状态测试，以及通过反应时间和运动时间对运动表现进行评估。从“开”期到“关”期观察到情绪恶化。尽管运动有明显变化，但从“开”期到“关”期未观察到认知表现的变化。“开 - 关”变化期间的情绪变化可能反映了中皮质和中边缘多巴胺能系统的参与。
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