Meco G, Bonifati V, Bedini L, Bellatreccia A, Vanacore N, Franzese A
Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma.
Ital J Neurol Sci. 1991 Feb;12(1):57-62. doi: 10.1007/BF02337615.
10 patients with Parkinson disease on long term levodopa therapy and with fluctuations in motor performance unrelated to drug administration (on-off phenomena) were assessed on the following neuropsychological tests during the on and off phases: tests of attention (Toulouse-Pieron), memory (Digit Span, Rey forms 1 and 2), psychomotor capacity (maze test, single and multiple choice reaction times) and mood (Maudley Adjective Check List). The extrapyramidal symptoms were assessed on the Webster Rating Scale. We found no significant differences in attention, cognitive performance or mood between the on and off phases despite large fluctuations in motor performance.
对10例长期接受左旋多巴治疗且运动表现波动与药物服用无关（开关现象）的帕金森病患者，在开期和关期进行了以下神经心理学测试：注意力测试（图卢兹-皮埃隆测试）、记忆力测试（数字广度、雷伊图形1和2）、精神运动能力测试（迷宫测试、单项和多项选择反应时间）以及情绪测试（莫兹利形容词检查表）。采用韦氏评定量表评估锥体外系症状。尽管运动表现波动很大，但我们发现开期和关期在注意力、认知表现或情绪方面无显著差异。
