Graduate School, Tianjin Medical University, Tianjin, China.
Beijing Wonderful Medical Biomaterials Co., Ltd., Beijing, China.
Cell Tissue Bank. 2024 Mar;25(1):357-367. doi: 10.1007/s10561-023-10097-x. Epub 2023 Jun 24.
Tendon injuries repair is a significant burden for orthopaedic surgeons. Finding a proper graft material to repair tendon is one of the main challenges in orthopaedics, for which the requirement of substitute for tendon repair would be different for each clinical application. Among biological scaffolds, the use of decellularized tendon increasingly represents an interesting approach to treat tendon injuries and several articles have investigated the approaches of tendon decellularization. To understand the outcomes of the the approaches of tendon decellularization on effect of tendon transplantation, a literature review was performed. This review was conducted by searching in Pubmed and Embase and 64 studies were included in this study. The findings revealed that the common approaches to decellularize tendon include chemical, physical, and enzymatic decellularization methods or their combination. With the development of tissue engineering, researchers also put forward new theories such as automatic acellular machine, 3D printing technology to manufacture acellular scaffold.
肌腱损伤修复是骨科医生面临的重大挑战。寻找合适的移植物材料来修复肌腱是骨科领域的主要挑战之一，因为每种临床应用对肌腱修复替代物的要求都不同。在生物支架中，脱细胞肌腱的使用越来越多地代表了一种治疗肌腱损伤的有趣方法，并且已经有几篇文章研究了肌腱脱细胞的方法。为了了解肌腱脱细胞方法对肌腱移植效果的影响，我们进行了文献回顾。这项研究通过在 Pubmed 和 Embase 中进行检索，共纳入了 64 项研究。研究结果表明，脱细胞肌腱的常见方法包括化学、物理和酶法脱细胞方法，或它们的组合。随着组织工程学的发展，研究人员还提出了新的理论，如自动脱细胞机、3D 打印技术来制造脱细胞支架。
