Bateman Grant Alexander, Bateman Alexander Robert
Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW 2305, Australia.
Faculty of Health, Callaghan Campus, University of Newcastle, Newcastle, NSW 2308, Australia.
J Clin Med. 2023 Oct 20;12(20):6646. doi: 10.3390/jcm12206646.
The cause of the cystic dilatation of the cord found in syringomyelia has been a source of conjecture for a considerable time. Recent studies have shown that there is a reduction in craniospinal compliance in both childhood hydrocephalus and multiple sclerosis which leads to venous outflow dilatation. Both diseases are associated with glymphatic outflow obstruction. Venous dilatation will narrow the perivenous glymphatic outflow pathway and lead to an increase in glymphatic outflow resistance. Syringomyelia has been shown to be associated with reduced spinal canal compliance. This paper discusses the possibility that venous dilatation and obstructed glymphatic outflow within the cord may be behind the cystic dilatation found within syringomyelia.
脊髓空洞症中发现的脊髓囊性扩张的病因在相当长的一段时间内一直是推测的来源。最近的研究表明，儿童脑积水和多发性硬化症患者的颅脊髓顺应性均降低，这会导致静脉流出道扩张。这两种疾病都与类淋巴系统流出受阻有关。静脉扩张会使静脉周围的类淋巴系统流出通道变窄，并导致类淋巴系统流出阻力增加。脊髓空洞症已被证明与椎管顺应性降低有关。本文探讨了脊髓内静脉扩张和类淋巴系统流出受阻可能是脊髓空洞症中发现的囊性扩张背后原因的可能性。
