冰山一角：环状RNA在血液系统恶性肿瘤中的作用
Tip of the iceberg: roles of circRNAs in hematological malignancies.
作者信息
Guo Shan-Shan, Li Bi-Xia, Zou Duo-Bing, Yang Shu-Jun, Sheng Li-Xia, Ouyang Gui-Fang, Mu Qi-Tian, Huang He
机构信息
Ningbo Hospital, School of Medicine, Zhejiang University Ningbo, Zhejiang, PR China.
Ningbo University School of Medicine Ningbo, Zhejiang, PR China.
出版信息
Am J Cancer Res. 2020 Feb 1;10(2):367-382. eCollection 2020.
Abstract
Circular RNAs (circRNAs) are a new class of covalently closed RNA molecules whose 3'- and 5'-ends are linked by a back-splicing event. Emerging evidence has shown that circRNAs play a vital role in the occurrence and development of many diseases and are promising biomarkers and therapeutic targets. However, knowledge of circRNAs in hematological malignancies is limited. In this review, the biogenesis, categories, characteristics, and functions of circRNAs are summarized, especially the roles of circRNAs in hematopoiesis and hematological malignancies.
摘要
环状RNA（circRNAs）是一类新的共价闭合RNA分子，其3'端和5'端通过反向剪接事件相连。越来越多的证据表明，circRNAs在许多疾病的发生和发展中起着至关重要的作用，有望成为生物标志物和治疗靶点。然而，关于血液系统恶性肿瘤中circRNAs的了解仍然有限。在这篇综述中，我们总结了circRNAs的生物合成、分类、特征和功能，特别是circRNAs在造血和血液系统恶性肿瘤中的作用。
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