锌限制和锌充足条件下肺炎克雷伯菌的磷酸化蛋白质组分析
Phosphoproteome Profiling of Klebsiella pneumoniae under Zinc-Limited and Zinc-Replete Conditions.
作者信息
Reitzel Chelsea, Sukumaran Arjun, Zanetti Christina, Muselius Benjamin, Geddes-McAlister Jennifer
机构信息
Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
出版信息
Microbiol Resour Announc. 2023 Jul 18;12(7):e0025823. doi: 10.1128/mra.00258-23. Epub 2023 Jun 26.
The bacterial pathogen Klebsiella pneumoniae causes nosocomial infections with the acquisition of multidrug resistance, impeding treatment options. This study investigated the effect of zinc limitation on the phosphoproteome of K. pneumoniae using quantitative mass spectrometry. New insight is provided into cellular signaling methods used by the pathogen to respond to nutrient-limited environments.
细菌病原体肺炎克雷伯菌会引发医院感染，并产生多重耐药性，这给治疗带来了阻碍。本研究采用定量质谱法研究了锌限制对肺炎克雷伯菌磷酸化蛋白质组的影响。该研究为病原体应对营养受限环境所采用的细胞信号传导方式提供了新的见解。
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