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铁限制和铁充足条件下肺炎克雷伯菌磷酸化蛋白质组分析

Profiling of the Klebsiella pneumoniae Phosphoproteome under Iron-Limited and Iron-Replete Conditions.

作者信息

Reitzel Chelsea, Sukumaran Arjun, Muselius Benjamin, O'Connor Siobhan, Geddes-McAlister Jennifer

机构信息

Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.

出版信息

Microbiol Resour Announc. 2023 Jul 18;12(7):e0018623. doi: 10.1128/mra.00186-23. Epub 2023 Jun 26.

DOI:10.1128/mra.00186-23
PMID:37358437
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10353416/
Abstract

Klebsiella pneumoniae was compared across iron-limited and iron-replete conditions to assess changes within the phosphoproteome using quantitative mass spectrometry. These comparative proteomic data provide insights into cellular responses to nutrient limitation and how nutrient requirements may be exploited to provide potential antimicrobial targets.

摘要

利用定量质谱技术，在铁限制和铁充足条件下对肺炎克雷伯菌进行比较，以评估磷酸化蛋白质组内的变化。这些比较蛋白质组学数据为细胞对营养限制的反应以及如何利用营养需求来提供潜在的抗菌靶点提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/10353416/335efaa969ee/mra.00186-23-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/10353416/335efaa969ee/mra.00186-23-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1809/10353416/335efaa969ee/mra.00186-23-f001.jpg

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Front Microbiol. 2020 Apr 24;11:546. doi: 10.3389/fmicb.2020.00546. eCollection 2020.
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Chemoproteomic Profiling of Phosphoaspartate Modifications in Prokaryotes.原核生物中磷酸天冬氨酸修饰的化学生物学蛋白质组学分析
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A Novel LC System Embeds Analytes in Pre-formed Gradients for Rapid, Ultra-robust Proteomics.
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