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GLUT2 在多个器官和组织中的葡萄糖代谢中的作用。

The role of GLUT2 in glucose metabolism in multiple organs and tissues.

机构信息

Endorcrine and Metabolism Department, Lanzhou University Second Hospital, Lanzhou, 730000, China.

Department of Infantile Endocrine Genetic Metabolism, Gansu Maternal and child Health Care Hospital, Lanzhou, 730000, China.

出版信息

Mol Biol Rep. 2023 Aug;50(8):6963-6974. doi: 10.1007/s11033-023-08535-w. Epub 2023 Jun 26.

DOI:10.1007/s11033-023-08535-w
PMID:37358764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10374759/
Abstract

The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in β-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis.

摘要

葡萄糖转运蛋白家族在葡萄糖代谢的初始阶段发挥着重要作用；葡萄糖转运蛋白 2（GLUT2，由溶质载体家族 2，SLC2A 基因编码）是胰岛β细胞和肝细胞中主要的葡萄糖转运蛋白，但也在小肠、肾脏和中枢神经系统中表达；GLUT2 对葡萄糖的亲和力较低。在生理条件下，GLUT2 将葡萄糖转运到细胞内，使葡萄糖浓度在细胞膜两侧达到平衡；GLUT2 的变异与各种内分泌和代谢紊乱有关；在本研究中，我们讨论了 GLUT2 在参与多个器官和组织的葡萄糖代谢和调节及其对维持葡萄糖内稳态的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90c/10374759/eb3aee6fcabd/11033_2023_8535_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90c/10374759/416ee0bc67a4/11033_2023_8535_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90c/10374759/eb3aee6fcabd/11033_2023_8535_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90c/10374759/416ee0bc67a4/11033_2023_8535_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e90c/10374759/eb3aee6fcabd/11033_2023_8535_Fig2_HTML.jpg

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The role of GLUT2 in glucose metabolism in multiple organs and tissues.

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本文引用的文献

[1]
Repetitive hypoglycemia reduces activation of glucose-responsive neurons in C1 and C3 medullary brain regions to subsequent hypoglycemia.

Am J Physiol Endocrinol Metab. 2019-4-23

[2]
WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells.

Diabetes. 2018-11-13

[3]
The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2.

Protein Cell. 2018-10-15

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Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.

Diabetologia. 2018-8-22

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Cell Physiol Biochem. 2018

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Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection.

Science. 2018-3-8

[7]
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Cell Physiol Biochem. 2017

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Bull Math Biol. 2017-6

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Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice.

J Physiol. 2016-8-1

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J Clin Invest. 2013-12-16

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