Terpstra H, de Jong M C, Klokke A H
Arch Dermatol. 1979 Mar;115(3):316-9.
Pemphigus vulgaris developed in a 23-year-old woman during the first trimester of pregnancy. In the 33d week she had a stillbirth of a female child who showed extensive skin lesions clinically suggestive of pemphigus. The application of direct immunofluorescence staining to skin tissue sections showed deposition of IgG in the intercellular spaces of the epidermis of both mother and child. Our findings raise the possibility of transplacentar passage of pemphigus antibody, which may have been responsible for the fetal skin lesions.
一名23岁女性在妊娠头三个月患上寻常型天疱疮。在第33周时，她产下一名死产女婴，该女婴临床上有广泛的皮肤病变，提示为天疱疮。对皮肤组织切片进行直接免疫荧光染色显示，母婴双方表皮细胞间隙均有IgG沉积。我们的研究结果提示天疱疮抗体可能经胎盘传递，这可能是导致胎儿皮肤病变的原因。
