Programa de Pós-Graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul (UFRGS), Ramiro Barcelos, 2400, Santa Cecília, Porto Alegre, RS, 90035-903, Brazil.
Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, RS, Brazil.
Sci Rep. 2023 Jun 26;13(1):10325. doi: 10.1038/s41598-023-36626-y.
This prospective cohort longitudinal study examines the risk factors associated with different intrauterine environments and the influence of different intrauterine environments on children's motor development at 3- and 6-months of life. Participants were 346 mother/newborn dyads enrolled in the first 24 to 48 h after delivery in public hospitals. Four groups with no concurrent condition composed the sample: mothers with a clinical diagnosis of diabetes, mothers with newborns small for gestational age due to idiopathic intrauterine growth restriction (IUGR), mothers who smoked tobacco during gestation, and a control group composed of mothers without clinical condition. Children were assessed at three- and six-months regarding motor development, weight, length, head circumference, and parents completed a socioeconomic questionnaire. The IUGR children had lower supine, sitting, and overall gross motor scores at 6 months than the other children's groups. Anthropometric and sociodemographic characteristics negatively influenced gross motor development. IUGR and anthropometric and sociodemographic characteristics negatively impact motor development. Intrauterine environment impact child neurodevelopment.
本前瞻性队列纵向研究探讨了与不同宫内环境相关的风险因素，以及不同宫内环境对儿童出生后 3 至 6 个月运动发育的影响。参与者为 346 对母婴二联体，均在分娩后 24 至 48 小时内在公立医院入组。样本由无并发疾病的四组组成：临床诊断为糖尿病的母亲、因特发性宫内生长受限（IUGR）导致新生儿小于胎龄的母亲、孕期吸烟的母亲和无临床疾病的对照组母亲。在出生后 3 至 6 个月时，对儿童的运动发育、体重、身长、头围进行评估，家长完成社会经济状况问卷。与其他儿童组相比，IUGR 儿童在 6 个月时仰卧位、坐位和整体粗大运动评分较低。人体测量学和社会人口学特征对粗大运动发育有负面影响。IUGR 以及人体测量学和社会人口学特征对运动发育有负面影响。宫内环境影响儿童神经发育。
