Bo G P, Fonzari M, Scotto P A, Benassi E
Exp Neurol. 1984 Jul;85(1):229-32. doi: 10.1016/0014-4886(84)90177-8.
We recorded spike activity induced by i.p. penicillin injections in eight rats, repeating the experiment five times per each rat, at 48-h intervals. Spike frequency was significantly reduced in all sessions subsequent to the first, without changes in penicillin blood concentrations. The penicillin model of epilepsy is therefore not advisable in studies on antiepileptic drugs with a crossover design.
我们记录了8只大鼠腹腔注射青霉素诱导的棘波活动，每只大鼠每隔48小时重复该实验5次。在首次实验后的所有实验中，棘波频率均显著降低，而青霉素血药浓度并无变化。因此，在采用交叉设计的抗癫痫药物研究中，青霉素癫痫模型并不适用。
