Nephrology Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Xinshi Area, Urumqi, 830000, China.
Heart Center, The First Affiliated Hospital of Xinjiang Medical University, No. 137 Xinshi Area, Urumqi, 830000, China.
Int Urol Nephrol. 2024 Jan;56(1):325-334. doi: 10.1007/s11255-023-03676-0. Epub 2023 Jun 27.
To investigate the risk factors of acute kidney injury (AKI) patients with acute myocardial infarction (AMI) and establish potential microRNA (miRNA) biomarkers in the peripheral blood of AMI-AKI patients.
Patients hospitalized from 2016 to 2020 and diagnosed with AMI (with AKI or without AKI groups) were recruited. The data of the two groups were compared and the risk factors of AMI-AKI were analyzed by logistic regression. The receiver operator characteristics (ROC) curve was drawn and the predictive value of risk factors in AMI-AKI was evaluated. Six AMI-AKI patients were selected and six healthy subjects were enrolled as the control. The peripheral blood samples of the two groups were collected for miRNA high-throughput sequencing.
A total of 300 AMI patients were collected, including 190 patients with AKI and 110 patients without AKI. Multivariate logistic regression analysis indicated that diastolic pressure (68-80 mmHg), urea nitrogen, creatinine, serum uric acid (SUA), aspartate aminotransferase (AST), and left ventricular ejection fraction were the dependent risk factors of AMI-AKI patients (P < 0.05). ROC curve showed that the incidence of AMI-AKI patients was most correlated with urea nitrogen, creatinine, and SUA. In addition, 60 differentially expressed miRNAs were identified between AMI-AKI and controls. Then, hsa-miR-2278, hsa-miR-1827, and hsa-miR-149-5p were more corrected with predictors. Twelve of them targeted 71 genes involved in phagosome, oxytocin signaling pathway, and microRNAs in cancer pathways.
Urea nitrogen, creatinine, and SUA were the dependent risk factors and important predictors for AMI-AKI patients. Three miRNAs may be considered as biomarkers for AMI-AKI.
探讨急性心肌梗死（AMI）合并急性肾损伤（AKI）患者的危险因素，并建立 AMI-AKI 患者外周血潜在的微小 RNA（miRNA）生物标志物。
纳入 2016 年至 2020 年住院并诊断为 AMI（伴 AKI 或不伴 AKI 组）的患者。比较两组患者的临床资料，采用 Logistic 回归分析 AMI-AKI 的危险因素，绘制受试者工作特征（ROC）曲线评估危险因素对 AMI-AKI 的预测价值。选取 6 例 AMI-AKI 患者和 6 例健康体检者作为对照，采集外周血样本进行 miRNA 高通量测序。
共纳入 300 例 AMI 患者，其中 AKI 患者 190 例，无 AKI 患者 110 例。多因素 Logistic 回归分析显示，舒张压（68-80mmHg）、尿素氮、肌酐、血尿酸（SUA）、天冬氨酸氨基转移酶（AST）、左心室射血分数是 AMI-AKI 患者的独立危险因素（P<0.05）。ROC 曲线显示，AMI-AKI 患者的发生率与尿素氮、肌酐、SUA 最相关。此外，AMI-AKI 患者与对照组之间共鉴定出 60 个差异表达 miRNA，其中 hsa-miR-2278、hsa-miR-1827 和 hsa-miR-149-5p 与预测因子的相关性更高。这 3 个 miRNA 可能作为 AMI-AKI 的生物标志物。
尿素氮、肌酐和 SUA 是 AMI-AKI 患者的独立危险因素和重要预测因子，3 个 miRNA 可能作为 AMI-AKI 的生物标志物。
