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利用植物乳杆菌和耐久肠球菌产生的透明质酸对紫外线引起的皮肤损伤进行光保护。

Photoprotection Against UV-Induced Skin Damage Using Hyaluronic Acid Produced by Lactiplantibacillus plantarum and Enterococcus durans.

机构信息

Department of Radiation Microbiology, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.

Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt.

出版信息

Curr Microbiol. 2023 Jun 27;80(8):262. doi: 10.1007/s00284-023-03377-y.

DOI:10.1007/s00284-023-03377-y
PMID:37369929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10299924/
Abstract

Exposure to ultraviolet (UV) radiation is one of the major factors that causes skin aging, erythema, sunburns, and skin cancer. This study aimed to select probiotic bacterial isolates able to produce high yield of hyaluronic acid (HA) to be employed for skin photoprotection and other possible biological applications. The selected isolates K11 and St3 were able to produce the highest yields of HA 4.8 and 4.4 mg/ml, respectively. Both isolates were identified as Enterococcus durans strain K11 and Lactiplantibacillus plantarum strain St3 using 16S rRNA gene sequencing. The antioxidant activity of HA produced by E. durans strain K11 and L. plantarum strain St3 was (65.4 0.2%) and (66.6 0.1%), respectively. The viability of UVB-irradiated keratinocytes pre-treated with HA produced by E. durans strain K11 and L. plantarum strain St3 was 91.3 and 91.4%, respectively, compared with the control. While the viability of UVB-irradiated keratinocytes post-treated with HA produced by E. durans strain K11 and L. plantarum strain St3 was 86 and 88.5%, respectively. To the best of our knowledge, this is the first recordation of HA production by Enterococcus durans and Lactiplantibacillus plantarum which revealed a significant radioprotection of the human keratinocytes against UVB radiation.

摘要

紫外线（UV）辐射暴露是导致皮肤衰老、红斑、晒伤和皮肤癌的主要因素之一。本研究旨在选择能够产生高产量透明质酸（HA）的益生菌细菌分离株，用于皮肤光保护和其他可能的生物学应用。所选的分离株 K11 和 St3 分别能够产生 4.8 和 4.4 mg/ml 的最高 HA 产量。这两种分离株均通过 16S rRNA 基因测序鉴定为屎肠球菌 K11 株和植物乳杆菌 St3 株。屎肠球菌 K11 株和植物乳杆菌 St3 株产生的 HA 的抗氧化活性分别为（65.4±0.2）%和（66.6±0.1）%。与对照组相比，经 UVB 照射的角质形成细胞预先用屎肠球菌 K11 株和植物乳杆菌 St3 株产生的 HA 处理后，其存活率分别为 91.3%和 91.4%。而经屎肠球菌 K11 株和植物乳杆菌 St3 株产生的 HA 处理后，经 UVB 照射的角质形成细胞的存活率分别为 86%和 88.5%。据我们所知，这是屎肠球菌和植物乳杆菌产生 HA 的首次记录，这揭示了 HA 对人类角质形成细胞对 UVB 辐射的显著防护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/db03286204bd/284_2023_3377_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/6422c65b7e9c/284_2023_3377_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/5a304f5a0945/284_2023_3377_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/b8bb4156a049/284_2023_3377_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/54063fca49cb/284_2023_3377_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/db03286204bd/284_2023_3377_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/6422c65b7e9c/284_2023_3377_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/5a304f5a0945/284_2023_3377_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/b8bb4156a049/284_2023_3377_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/54063fca49cb/284_2023_3377_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3205/10299924/db03286204bd/284_2023_3377_Fig5_HTML.jpg

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