Dho Matteo, Candian Valentina, Tedeschi Rosemarie
Dipartimento di Scienze Agrarie, Forestali e Alimentari (DISAFA), University of Torino, Largo P. Braccini 2, 10095 Grugliasco, Italy.
Antibiotics (Basel). 2023 May 24;12(6):952. doi: 10.3390/antibiotics12060952.
Several insects are known as vectors of a wide range of animal and human pathogens causing various diseases. However, they are also a source of different substances, such as the Antimicrobial Peptides (AMPs), which can be employed in the development of natural bioactive compounds for medical, veterinary and agricultural applications. It is well known that AMP activity, in contrast to most classical antibiotics, does not lead to the development of natural bacterial resistance, or at least the frequency of resistance is considered to be low. Therefore, there is a strong interest in assessing the efficacy of the various peptides known to date, identifying new compounds and evaluating possible solutions in order to increase their production. Moreover, implementing AMP modulation in insect rearing could preserve insect health in large-scale production. This review describes the current knowledge on insect AMPs, presenting the validated ones for the different insect orders. A brief description of their mechanism of action is reported with focus on proposed applications. The possible effects of insect diet on AMP translation and synthesis have been discussed.
几种昆虫被认为是多种动物和人类病原体的传播媒介，可引发各种疾病。然而，它们也是不同物质的来源，比如抗菌肽（AMPs），这些抗菌肽可用于开发用于医学、兽医和农业应用的天然生物活性化合物。众所周知，与大多数传统抗生素不同，抗菌肽的活性不会导致天然细菌耐药性的产生，或者至少耐药频率被认为较低。因此，人们对评估迄今已知的各种肽的功效、鉴定新化合物以及评估可能的解决方案以提高其产量有着浓厚兴趣。此外，在昆虫饲养中实施抗菌肽调节可以在大规模生产中保持昆虫健康。本综述描述了关于昆虫抗菌肽的现有知识，介绍了不同昆虫目的已验证抗菌肽。报告了它们的作用机制，并重点介绍了拟议的应用。还讨论了昆虫饮食对抗菌肽翻译和合成的可能影响。
