Kozhukhar Natalya, Alexeyev Mikhail F
Department of Physiology and Cell Biology, University of South Alabama, Mobile, AL 36688, USA.
Biology (Basel). 2023 Jun 6;12(6):823. doi: 10.3390/biology12060823.
Transcription Factor A Mitochondrial (TFAM), through its contributions to mtDNA maintenance and expression, is essential for cellular bioenergetics and, therefore, for the very survival of cells. Thirty-five years of research on TFAM structure and function generated a considerable body of experimental evidence, some of which remains to be fully reconciled. Recent advancements allowed an unprecedented glimpse into the structure of TFAM complexed with promoter DNA and TFAM within the open promoter complexes. These novel insights, however, raise new questions about the function of this remarkable protein. In our review, we compile the available literature on TFAM structure and function and provide some critical analysis of the available data.
线粒体转录因子A（TFAM）通过对线粒体DNA（mtDNA）的维持和表达发挥作用，对于细胞生物能量学至关重要，因而对细胞的生存也至关重要。三十五年对TFAM结构和功能的研究产生了大量实验证据，其中一些仍有待完全梳理清楚。最近的进展使人们得以以前所未有的视角了解与启动子DNA复合的TFAM结构以及开放启动子复合物中的TFAM结构。然而，这些新见解也引发了关于这种非凡蛋白质功能的新问题。在我们的综述中，我们汇编了有关TFAM结构和功能的现有文献，并对现有数据进行了一些批判性分析。
