Papaporfyriou Anastasia, Bartziokas Konstantinos, Gompelmann Daniela, Idzko Marco, Fouka Evangelia, Zaneli Stavrina, Bakakos Petros, Loukides Stelios, Papaioannou Andriana I
Division of Pulmonology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria.
Independent Researcher, 42132 Trikala, Greece.
Life (Basel). 2023 May 31;13(6):1299. doi: 10.3390/life13061299.
Chronic obstructive pulmonary disease (COPD) is considered one of the leading causes of mortality. Cardiovascular comorbidities are diagnosed often in COPD patients, not only because of the common risk factors these two diseases share, but also because of the systemic inflammation which characterizes COPD and has deleterious effects in the cardiovascular system. The comorbid cardiovascular diseases in COPD result in several difficulties in the holistic treatment of these patients and affect outcomes such as morbidity and mortality. Several studies have reported that mortality from cardiovascular causes is common among COPD patients, while the risk for acute cardiovascular events increases during COPD exacerbations and remains high for a long time even after recovery. In this review, we focus on the prevalence of cardiovascular comorbidities in COPD patients, presenting the evidence regarding the interaction of the pathophysiological pathways which characterize each disease. Furthermore, we summarize information regarding the effects of cardiovascular treatment on COPD outcomes and vice versa. Finally, we present the current evidence regarding the impact of cardiovascular comorbidities on exacerbations, quality of life and survival of COPD patients.
慢性阻塞性肺疾病（COPD）被认为是主要的死亡原因之一。COPD患者常被诊断出患有心血管合并症，这不仅是因为这两种疾病有共同的危险因素，还因为COPD所特有的全身炎症对心血管系统有有害影响。COPD患者的合并心血管疾病给这些患者的整体治疗带来了一些困难，并影响发病率和死亡率等预后。多项研究报告称，心血管疾病导致的死亡在COPD患者中很常见，而在COPD急性加重期间，急性心血管事件的风险会增加，并且即使在恢复后很长一段时间内仍居高不下。在这篇综述中，我们关注COPD患者心血管合并症的患病率，展示有关每种疾病特征性病理生理途径相互作用的证据。此外，我们总结了有关心血管治疗对COPD预后的影响以及反之亦然的信息。最后，我们展示了有关心血管合并症对COPD患者急性加重、生活质量和生存影响的现有证据。
