Wu Jiahe, Zhang Bo, Lin Nengming, Gao Jianqing
Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Biomater Sci. 2023 Feb 28;11(5):1648-1664. doi: 10.1039/d2bm01783k.
Biofilm formation plays an important role in the resistance development in bacteria to conventional antibiotics. Different properties of the bacterial strains within biofilms compared with their planktonic states and the protective effect of extracellular polymeric substances contribute to the insusceptibility of bacterial cells to conventional antimicrobials. Although great effort has been devoted to developing novel antibiotics or synthetic antibacterial compounds, their efficiency is overshadowed by the growth of drug resistance. Developments in nanotechnology have brought various feasible strategies to combat biofilms by interfering with the biofilm life cycle. In this review, recent nanotechnology-based strategies for interfering with the biofilm life cycle according to the requirements of different stages are summarized. Additionally, the importance of strategies that modulate the bacterial biofilm microenvironment is also illustrated with specific examples. Lastly, we discussed the remaining challenges and future perspectives on nanotechnology-based strategies for the treatment of bacterial infection.
生物膜形成在细菌对传统抗生素的耐药性发展中起着重要作用。与浮游状态相比，生物膜内细菌菌株的不同特性以及细胞外聚合物的保护作用导致细菌细胞对传统抗菌药物不敏感。尽管人们付出了巨大努力来开发新型抗生素或合成抗菌化合物，但耐药性的增长使它们的效果黯然失色。纳米技术的发展带来了各种可行的策略，通过干扰生物膜生命周期来对抗生物膜。在这篇综述中，总结了根据不同阶段的要求基于纳米技术干扰生物膜生命周期的最新策略。此外，还通过具体例子说明了调节细菌生物膜微环境策略的重要性。最后，我们讨论了基于纳米技术治疗细菌感染策略所面临的剩余挑战和未来前景。
