Department of Orthopedics, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, China.
Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
Molecules. 2023 Jun 15;28(12):4790. doi: 10.3390/molecules28124790.
Calcium phosphate is the main inorganic component of bone. Calcium phosphate-based biomaterials have demonstrated great potential in bone tissue engineering due to their superior biocompatibility, pH-responsive degradability, excellent osteoinductivity, and similar components to bone. Calcium phosphate nanomaterials have gained more and more attention for their enhanced bioactivity and better integration with host tissues. Additionally, they can also be easily functionalized with metal ions, bioactive molecules/proteins, as well as therapeutic drugs; thus, calcium phosphate-based biomaterials have been widely used in many other fields, such as drug delivery, cancer therapy, and as nanoprobes in bioimaging. Thus, the preparation methods of calcium phosphate nanomaterials were systematically reviewed, and the multifunction strategies of calcium phosphate-based biomaterials have also been comprehensively summarized. Finally, the applications and perspectives of functionalized calcium phosphate biomaterials in bone tissue engineering, including bone defect repair, bone regeneration, and drug delivery, were illustrated and discussed by presenting typical examples.
磷酸钙是骨骼的主要无机成分。基于磷酸钙的生物材料由于其优异的生物相容性、pH 响应降解性、出色的成骨诱导性以及与骨骼相似的成分，在骨组织工程中显示出巨大的潜力。磷酸钙纳米材料因其增强的生物活性和更好地与宿主组织结合而受到越来越多的关注。此外，它们还可以很容易地与金属离子、生物活性分子/蛋白质以及治疗药物进行功能化；因此，基于磷酸钙的生物材料已广泛应用于许多其他领域，如药物输送、癌症治疗以及生物成像中的纳米探针。因此，本文系统地综述了磷酸钙纳米材料的制备方法，并全面总结了基于磷酸钙的生物材料的多功能策略。最后，通过展示典型实例，说明了功能化磷酸钙生物材料在骨组织工程中的应用和前景，包括骨缺损修复、骨再生和药物输送。
