Sustainable Innovative Biomaterials Department, Le Qara Research Center, Arequipa 04000, Peru.
Bioprocess Engineering and Biotechnology Department, Federal University of Paraná-Polytechnic Center, Curitiba 81531-980, Brazil.
Molecules. 2023 Jun 18;28(12):4838. doi: 10.3390/molecules28124838.
Nanotechnology is an innovative field of study that has made significant progress due to its potential versatility and wide range of applications, precisely because of the development of metal nanoparticles such as copper. Nanoparticles are bodies composed of a nanometric cluster of atoms (1-100 nm). Biogenic alternatives have replaced their chemical synthesis due to their environmental friendliness, dependability, sustainability, and low energy demand. This ecofriendly option has medical, pharmaceutical, food, and agricultural applications. When compared to their chemical counterparts, using biological agents, such as micro-organisms and plant extracts, as reducing and stabilizing agents has shown viability and acceptance. Therefore, it is a feasible alternative for rapid synthesis and scaling-up processes. Several research articles on the biogenic synthesis of copper nanoparticles have been published over the past decade. Still, none provided an organized, comprehensive overview of their properties and potential applications. Thus, this systematic review aims to assess research articles published over the past decade regarding the antioxidant, antitumor, antimicrobial, dye removal, and catalytic activities of biogenically synthesized copper nanoparticles using the scientific methodology of big data analytics. Plant extract and micro-organisms (bacteria and fungi) are addressed as biological agents. We intend to assist the scientific community in comprehending and locating helpful information for future research or application development.
纳米技术是一个创新性的研究领域，由于其潜在的多功能性和广泛的应用，取得了重大进展，这正是由于金属纳米粒子（如铜）的发展。纳米粒子是由纳米级原子簇（1-100nm）组成的物体。由于其环保、可靠、可持续和低能耗的特点，生物替代物已经取代了它们的化学合成。这种环保的选择在医疗、制药、食品和农业领域都有应用。与化学合成物相比，使用生物制剂（如微生物和植物提取物）作为还原剂和稳定剂具有可行性和可接受性。因此，它是快速合成和扩大规模过程的可行替代方案。过去十年中已经发表了许多关于生物合成铜纳米粒子的研究文章，但没有一篇文章对其性质和潜在应用提供全面、综合的概述。因此，本系统评价旨在使用大数据分析的科学方法评估过去十年中发表的关于生物合成铜纳米粒子的抗氧化、抗肿瘤、抗菌、染料去除和催化活性的研究文章。植物提取物和微生物（细菌和真菌）被视为生物制剂。我们旨在帮助科学界理解和找到有价值的信息，为未来的研究或应用开发提供帮助。
