Hennig C W, Steinhoff W C, Booth J V
Pharmacol Biochem Behav. 1986 Jun;24(6):1623-7. doi: 10.1016/0091-3057(86)90496-x.
The effects of low and high doses of serotonin on tonic immobility (TI) duration and susceptibility in 10- and 45-day-old chickens were examined. High doses of serotonin reduced the number of inductions required to produce TI, regardless of the subject's age. In contrast, low and high doses of serotonin produced biphasic increases and decreases in TI duration in 10-day-old birds, but there were no apparent effects on immobility duration by either dose of this drug in older chickens. These results are discussed in terms of the formation of the blood-brain barrier in domestic fowl and the differential peripheral versus central actions by serotonin on TI susceptibility and response duration.
研究了低剂量和高剂量血清素对10日龄和45日龄雏鸡强直静止（TI）持续时间和易感性的影响。无论雏鸡年龄大小，高剂量血清素均可减少诱导产生TI所需的次数。相比之下，低剂量和高剂量血清素使10日龄雏鸡的TI持续时间呈双相增加和减少，但该药物的任何一种剂量对大龄雏鸡的静止持续时间均无明显影响。根据家鸡血脑屏障的形成以及血清素对TI易感性和反应持续时间的外周与中枢作用差异对这些结果进行了讨论。
