Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Infectious Disease Translational Research Programme and Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Viruses. 2023 Jun 15;15(6):1377. doi: 10.3390/v15061377.
Dengue virus (DENV) is the cause of dengue fever, infecting 390 million people worldwide per year. It is transmitted to humans through the bites of mosquitoes and could potentially develop severe symptoms. In spite of the rising social and economic impact inflicted by the disease on the global population, a conspicuous lack of efficacious therapeutics against DENV still persists. In this study, catechin, a natural polyphenol compound, was evaluated as a DENV infection inhibitor in vitro. Through time-course studies, catechin was shown to inhibit a post-entry stage of the DENV replication cycle. Further investigation revealed its role in affecting viral protein translation. Catechin inhibited the replication of all four DENV serotypes and chikungunya virus (CHIKV). Together, these results demonstrate the ability of catechin to inhibit DENV replication, hinting at its potential to be used as a starting scaffold for further development of antivirals against DENV infection.
登革热病毒（DENV）是登革热的病原体，每年在全球感染 3.9 亿人。它通过蚊子的叮咬传播给人类，并可能发展为严重症状。尽管该疾病对全球人口造成的社会和经济影响日益严重，但针对 DENV 的有效治疗方法仍然明显缺乏。在这项研究中，儿茶素作为一种天然多酚化合物，在体外被评估为 DENV 感染抑制剂。通过时程研究，儿茶素被证明可以抑制 DENV 复制周期的进入后阶段。进一步的研究揭示了它在影响病毒蛋白翻译中的作用。儿茶素抑制了所有四种 DENV 血清型和基孔肯雅病毒（CHIKV）的复制。总之，这些结果表明儿茶素能够抑制 DENV 的复制，暗示它有可能被用作进一步开发针对 DENV 感染的抗病毒药物的起始支架。
