SARS-CoV-2 状态和衰老对居住在养老院的老年个体的鼻腔和粪便免疫谱的影响。
Influence of SARS-CoV-2 Status and Aging on the Nasal and Fecal Immunological Profiles of Elderly Individuals Living in Nursing Homes.
机构信息
Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain.
出版信息
Viruses. 2023 Jun 20;15(6):1404. doi: 10.3390/v15061404.
In the frame of SARS-CoV-2 infection, studies regarding cytokine profiling of mucosal-related samples are scarce despite being the primary infection sites. The objective of this study was to compare the nasal and fecal inflammatory profiles of elderly individuals living in a nursing home highly affected by COVID-19 (ELD1) with those of elderly individuals living in a nursing home with no cases of SARS-CoV-2 infection (ELD2) and, also, with those of healthy SARS-CoV-2-negative younger adults (YHA). BAFF/TNFSF13B, IL6, IL10 and TNF-α (immunological hallmarks of SARS-CoV-2 infection) were the only immune factors whose concentrations were different in the three groups. Their highest concentrations were achieved in the ELD1 group. Nasal and fecal concentrations of a wide number of pro-inflammatory cytokines were similar in the ELD1 and ELD2 groups but higher than those found in the YHA samples. These results reinforce the hypothesis that immunosenescence and inflammaging rendered the elderly as a highly vulnerable population to a neo-infection, such as COVID-19, which was evidenced during the first pandemic waves.
在 SARS-CoV-2 感染的框架内，尽管鼻腔和肠道是病毒感染的主要部位，但有关黏膜相关样本细胞因子谱的研究仍然很少。本研究的目的是比较受 COVID-19 高度影响的养老院中的老年个体（ELD1）与未感染 SARS-CoV-2 的养老院中的老年个体（ELD2）以及健康的 SARS-CoV-2 阴性年轻个体（YHA）的鼻腔和粪便的炎症特征。BAFF/TNFSF13B、IL6、IL10 和 TNF-α（SARS-CoV-2 感染的免疫特征）是三组之间浓度不同的唯一免疫因子。它们在 ELD1 组中的浓度最高。在 ELD1 和 ELD2 组中，许多促炎细胞因子的鼻腔和粪便浓度相似，但高于 YHA 样本中的浓度。这些结果支持了免疫衰老和炎症老化使老年人成为易感染新型感染（如 COVID-19）的高度脆弱人群的假说，这在第一次大流行浪潮中得到了证实。
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