Mozota Marta, Castro Irma, Gómez-Torres Natalia, Arroyo Rebeca, Lailla Yolanda, Somada Mario, Alba Claudio, Rodríguez Juan Miguel
Department of Nutrition and Food Science, Complutense University of Madrid, 28040 Madrid, Spain.
Villa Villera, 22142 Sieso de Huesca, Spain.
Foods. 2021 Sep 11;10(9):2149. doi: 10.3390/foods10092149.
The elderly population living in nursing homes is particularly vulnerable to COVID-19 although individual susceptibility to SARS-CoV-2 infection may be related to the host microbiota. The objective of this work was to investigate the effect of MP101 on the functional (Barthel index), cognitive (GDS/FAST), and nutritional (MNA) status as well as on the nasal and fecal inflammatory profiles of elderly residents living in a nursing home that is highly affected by COVID-19. A total of 25 residents participated in the trial, which involved the daily ingestion of a dairy product ( MP101: 9.3 log CFU per unit) for 4 months. Nasal and fecal samples were analyzed for 37 immune factors at recruitment and at the end of the study. After the trial, no change in the GDS/FAST scores were found but, in contrast, the values for the Barthel index and the MNA score improved significantly. The concentrations of some immune factors changed significantly after the trial, including a decrease in the concentrations of BAFF/TNFSF13B, APRIL/TNFSF13, IL8, IL31, osteopontin, sTNF-R1, and sTNF-R2, and an increase in chitinase 3-like 1, IL19, IL35, and pentraxin 3 was also observed. In conclusion, MP101 seems to be a promising strain for improving or maintaining health in this highly vulnerable population.
居住在养老院的老年人群体尤其容易感染新冠病毒，尽管个体对SARS-CoV-2感染的易感性可能与宿主微生物群有关。这项研究的目的是调查MP101对一家受新冠疫情严重影响的养老院老年居民的功能（巴氏指数）、认知（老年抑郁量表/功能评估分期）和营养（微型营养评定法）状况以及鼻腔和粪便炎症特征的影响。共有25名居民参与了该试验，试验内容为连续4个月每日摄入一种乳制品（MP101：每单位9.3 log CFU）。在招募时和研究结束时，对鼻腔和粪便样本中的37种免疫因子进行了分析。试验结束后，未发现老年抑郁量表/功能评估分期评分有变化，但相比之下，巴氏指数和微型营养评定法评分值显著改善。试验后，一些免疫因子的浓度发生了显著变化，包括BAFF/TNFSF13B、增殖诱导配体/TNFSF13、白细胞介素8、白细胞介素31、骨桥蛋白、可溶性肿瘤坏死因子受体1和可溶性肿瘤坏死因子受体2的浓度降低，同时还观察到几丁质酶3样蛋白1、白细胞介素19、白细胞介素35和五聚素3的浓度升高。总之，MP101似乎是改善或维持这一高度脆弱人群健康的一种有前景的菌株。
