Prakash Annamneedi Venkata, Park Il-Ho, Park Jun Woo, Bae Jae Pil, Lee Geum Seon, Kang Tae Jin
Department of Pharmacy and Institute of Chronic Disease, Sahmyook University, Seoul 01795, Republic of Korea.
Department of Counseling and Psychology, Sahmyook University, Seoul 01795, Republic of Korea.
Biomol Ther (Seoul). 2023 Jul 1;31(4):395-401. doi: 10.4062/biomolther.2023.099.
Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.
固有免疫是机体的第一道防御系统，用于感知危险信号，如病原微生物或细胞应激的宿主来源信号。存在于细胞膜中的模式识别受体（PRR）通过病原体相关分子模式（PAMP）来怀疑感染，并通过巨噬细胞和中性粒细胞等炎症细胞以及细胞因子激活固有免疫以促进炎症反应。炎性小体是蛋白质复合物，是炎症中固有免疫的一部分，用于清除病原体和修复受损组织。炎症在疾病中起什么重要作用？在本综述中，我们重点关注NLRP3炎性小体在哮喘、特应性皮炎和脓毒症等炎症性疾病中的作用机制。
