人类与食蟹猴胎盘发育的异同。
Similarities and differences in placental development between humans and cynomolgus monkeys.
作者信息
Matsumoto Shoma, Okamura Eiichi, Muto Masanaga, Ema Masatsugu
机构信息
Department of Stem Cells and Human Disease Models, Research Center for Animal Life Science Shiga University of Medical Science Otsu Japan.
Institute for the Advanced Study of Human Biology (WPI-ASHBi) Kyoto University Kyoto Japan.
出版信息
Reprod Med Biol. 2023 Jun 26;22(1):e12522. doi: 10.1002/rmb2.12522. eCollection 2023 Jan-Dec.
BACKGROUND
The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons.
METHODS
We analyzed the anatomical localization of each trophoblastic subtype in the cynomolgus monkey placenta by immunohistochemistry in the early second trimester. Histological differences among the mouse, cynomolgus monkey, and human placenta were compared. The PubMed database was used to search for studies on placentation in rodents and primates.
MAIN FINDINGS
The anatomical structures and subtypes of the placenta in cynomolgus monkeys are highly similar to those in humans, with the exception of fewer interstitial extravillous trophoblasts in cynomolgus monkeys.
CONCLUSION
The cynomolgus monkey appears to be a good animal model to investigate human placentation.
背景
胎盘是一个胚外器官，对维持正常妊娠至关重要。然而，由于技术和伦理原因，人类胎盘发育情况尚不清楚。
方法
我们在妊娠中期早期通过免疫组织化学分析了食蟹猴胎盘中各滋养层亚型的解剖定位。比较了小鼠、食蟹猴和人类胎盘的组织学差异。使用PubMed数据库搜索关于啮齿动物和灵长类动物胎盘形成的研究。
主要发现
食蟹猴胎盘的解剖结构和亚型与人类高度相似，只是食蟹猴的间质绒毛外滋养层较少。
结论
食蟹猴似乎是研究人类胎盘形成的良好动物模型。
Zotero 插件