Department of Health Professions, Manchester Metropolitan University, Manchester, United Kingdom.
Lifestyle Diseases, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
Front Public Health. 2023 Jun 9;11:1098100. doi: 10.3389/fpubh.2023.1098100. eCollection 2023.
Low back pain (LBP) is a common health problem, and the leading cause of activity limitation and work absence among people of all ages and socioeconomic strata. This study aimed to analyse the clinical and economic burden of LBP in high income countries (HICs) via systematic review and meta-analysis.
A literature search was carried out on PubMed, Medline, CINAHL, PsycINFO, AMED, and Scopus databases was from inception to March 15th, 2023. Studies that assessed the clinical and economic burden of LBP in HICs and published in English language were reviewed. The methodological quality of the included studies was assessed using the Newcastle-Ottawa quality assessment scale (NOS) for cohort studies. Two reviewers, using a predefined data extraction form, independently extracted data. Meta-analyses were conducted for clinical and economic outcomes.
The search identified 4,081 potentially relevant articles. Twenty-one studies that met the eligibility criteria were included and reviewed in this systematic review and meta-analysis. The included studies were from the regions of America ( = 5); Europe ( = 12), and the Western Pacific ( = 4). The average annual direct and indirect costs estimate per population for LBP ranged from € 2.3 billion to € 2.6 billion; and € 0.24 billion to $8.15 billion, respectively. In the random effects meta-analysis, the pooled annual rate of hospitalization for LBP was 3.2% (95% confidence interval 0.6%-5.7%). The pooled direct costs and total costs of LBP per patients were USD 9,231 (95% confidence interval -7,126.71-25,588.9) and USD 10,143.1 (95% confidence interval 6,083.59-14,202.6), respectively.
Low back pain led to high clinical and economic burden in HICs that varied significantly across the geographical contexts. The results of our analysis can be used by clinicians, and policymakers to better allocate resources for prevention and management strategies for LBP to improve health outcomes and reduce the substantial burden associated with the condition.
https://www.crd.york.ac.uk/prospero/#recordDetails?, PROSPERO [CRD42020196335].
腰痛（LBP）是一种常见的健康问题，也是所有年龄段和社会经济阶层人群活动受限和缺勤的主要原因。本研究旨在通过系统评价和荟萃分析分析高收入国家（HICs）的 LBP 临床和经济负担。
对 PubMed、Medline、CINAHL、PsycINFO、AMED 和 Scopus 数据库进行了文献检索，检索时间从开始到 2023 年 3 月 15 日。综述了评估 HICs 中 LBP 临床和经济负担的英语文献，并进行了研究。使用纽卡斯尔-渥太华质量评估量表（NOS）对队列研究进行了纳入研究的方法学质量评估。两名审查员使用预定义的数据提取表格独立提取数据。对临床和经济结果进行荟萃分析。
检索确定了 4081 篇潜在相关文章。21 项符合纳入标准的研究被纳入本系统评价和荟萃分析。纳入的研究来自美洲地区（=5）；欧洲（=12）和西太平洋地区（=4）。LBP 人群每年的直接和间接成本估计值范围分别为 23 亿欧元至 26 亿欧元；和 2.4 亿美元至 81.5 亿美元。在随机效应荟萃分析中，LBP 的住院率年合并率为 3.2%（95%置信区间 0.6%-5.7%）。每位患者的 LBP 直接成本和总成本的汇总值分别为 9231 美元（95%置信区间-7126.71-25588.9）和 10143.1 美元（95%置信区间 6083.59-14202.6）。
腰痛在 HICs 中导致了高临床和经济负担，并且在地理背景上存在显著差异。我们分析的结果可以为临床医生和决策者提供信息，以便更好地分配资源，制定预防和管理腰痛的策略，改善健康结果，减轻与该疾病相关的巨大负担。
https://www.crd.york.ac.uk/prospero/#recordDetails?, PROSPERO [CRD42020196335]。
