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根据国际小儿肝脏肿瘤共识对肝母细胞瘤分类的最新更新。

Recent updates on the classification of hepatoblastoma according to the International Pediatric Liver Tumors Consensus.

作者信息

Jeong Se Un, Kang Hyo Jeong

机构信息

Department of Pathology, University of Ulsan College of Medicine, Seoul, Korea.

Asan Liver Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

出版信息

J Liver Cancer. 2022 Mar;22(1):23-29. doi: 10.17998/jlc.2022.02.24. Epub 2022 Mar 17.

DOI:10.17998/jlc.2022.02.24
PMID:37383535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10035708/
Abstract

Hepatoblastoma is the most common pediatric liver malignancy and usually occurs within the first 3 years of life. In recent years, the overall incidence of hepatoblastoma has exhibited the greatest increase among all pediatric malignancies worldwide. The diagnosis of hepatoblastoma may be challenging due to the lack of a current consensus classification system. The International Pediatric Liver Tumors Consensus introduced guidelines and a consensus classification for the diagnosis of hepatoblastoma as either epithelial or mixed epithelial and mesenchymal and in the updated 5th edition of the World Health Organization Classification of Digestive System Tumors.

摘要

肝母细胞瘤是最常见的儿童肝脏恶性肿瘤，通常发生在生命的头3年内。近年来，肝母细胞瘤的总体发病率在全球所有儿童恶性肿瘤中上升幅度最大。由于缺乏当前的共识分类系统，肝母细胞瘤的诊断可能具有挑战性。国际儿童肝脏肿瘤共识在世界卫生组织消化系统肿瘤分类第5版更新版中引入了肝母细胞瘤诊断的指南和共识分类，将其分为上皮型或上皮和间充质混合型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/6a2b18cd6492/jlc-2022-02-24f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/7fb81743103d/jlc-2022-02-24f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/ce8e27bea04c/jlc-2022-02-24f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/84b7a56d9b88/jlc-2022-02-24f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/6a2b18cd6492/jlc-2022-02-24f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/7fb81743103d/jlc-2022-02-24f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/ce8e27bea04c/jlc-2022-02-24f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/84b7a56d9b88/jlc-2022-02-24f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e8/10035708/6a2b18cd6492/jlc-2022-02-24f4.jpg

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本文引用的文献

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2
Incidence trends and survival prediction of hepatoblastoma in children: a population-based study.儿童肝母细胞瘤的发病趋势和生存预测：一项基于人群的研究。
Cancer Commun (Lond). 2019 Oct 24;39(1):62. doi: 10.1186/s40880-019-0411-7.
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Do pregnancy characteristics contribute to rising childhood cancer incidence rates in the United States?妊娠特征是否导致美国儿童癌症发病率上升？
Genes (Basel). 2024 Oct 22;15(11):1358. doi: 10.3390/genes15111358.
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Adult Hepatoblastoma and Concomitant Hepatitis B Infection.成人肝母细胞瘤与乙型肝炎病毒合并感染
ACG Case Rep J. 2024 Sep 5;11(9):e01491. doi: 10.14309/crj.0000000000001491. eCollection 2024 Sep.
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A rare case report: multiple intrahepatic masses in a pediatric patient with citrin deficiency.一例罕见病例报告：一名患有瓜氨酸血症Ⅱ型的儿科患者出现多发肝内肿块。
Discov Oncol. 2024 May 31;15(1):200. doi: 10.1007/s12672-024-01059-0.
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Advances in Histological and Molecular Classification of Hepatocellular Carcinoma.肝细胞癌组织学和分子分类的进展
Biomedicines. 2023 Sep 20;11(9):2582. doi: 10.3390/biomedicines11092582.
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