Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Centro di Salute Globale, Università Cattolica del Sacro Cuore, Rome, Italy.
Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy.
Lancet Microbe. 2023 Sep;4(9):e745-e756. doi: 10.1016/S2666-5247(23)00115-5. Epub 2023 Jun 26.
In this Personal View, we discuss current knowledge on SARS-CoV-2 RNA or antigen persistence in children infected with SARS-CoV-2. Based on the evidence that the virus can persist in adults, we have done a literature review and analysed studies that looked for SARS-CoV-2 RNA or antigens in children undergoing autopsy, biopsy, or surgery for either death from COVID-19 or multisystem inflammatory syndrome, or assessments for long COVID-19 or other conditions. Our analysis suggests that in children, independent from disease severity, SARS-CoV-2 can spread systemically and persist for weeks to months. We discuss what is known about the biological effects of viral persistence for other viral infections and highlight new scenarios for clinical, pharmacological, and basic research exploration. Such an approach will improve the understanding and management of post-viral syndromes.
在这篇观点文章中，我们讨论了目前关于感染 SARS-CoV-2 的儿童中 SARS-CoV-2 RNA 或抗原持续存在的知识。基于病毒可以在成人中持续存在的证据，我们进行了文献回顾，并分析了对因 COVID-19 死亡或多系统炎症综合征而接受尸检、活检或手术的儿童，或对长 COVID-19 或其他疾病进行评估的研究，以寻找 SARS-CoV-2 RNA 或抗原。我们的分析表明，无论疾病严重程度如何，SARS-CoV-2 均可在儿童体内全身传播并持续数周至数月。我们讨论了关于其他病毒感染中病毒持续存在的生物学影响的已知情况，并强调了临床、药理学和基础研究探索的新情况。这种方法将有助于提高对病毒性综合征的理解和管理。
