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新型冠状病毒感染后儿童的细胞因子谱：初步研究结果

Cytokine Profile in Children Following SARS-CoV-2 Infection: Preliminary Findings.

作者信息

Buonsenso Danilo, Camporesi Anna, Di Sante Gabriele, Sali Michela, Boza Maria Del Carmen Pereyra, Morello Rosa, Valentini Piero, Raffaelli Francesca, Rodriguez Lucie, Gonzalez Laura, Johnsson Anette, Mugabo Constantin Habimana, Lakshmikanth Tadepally, Brodin Petter

机构信息

From the Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Centers for Global Health Research Studies, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

Pediatr Infect Dis J. 2025 Jan 1;44(1):54-57. doi: 10.1097/INF.0000000000004558. Epub 2024 Oct 1.

DOI:10.1097/INF.0000000000004558
PMID:39352145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11627325/
Abstract

We provide preliminary evidence that, also in children, Long coronavirus disease (COVID) may be characterized by a proinflammatory signature. Ten Long COVID patients, 7 convalescent subjects after COVID infection and 4 healthy controls were enrolled. When adjusted for sex, children with long COVID had statistically significant differences in the levels of Flt3L, CD5, uPA, CCL23, CD40 and TGFα. When adjusted for age, CCL23 levels remained statistically significant.

摘要

我们提供了初步证据，表明在儿童中，长期新冠病毒病（COVID）也可能具有促炎特征。招募了10名长期新冠患者、7名新冠感染后的康复者和4名健康对照。在对性别进行调整后，长期新冠儿童在Flt3L、CD5、uPA、CCL23、CD40和TGFα水平上存在统计学显著差异。在对年龄进行调整后，CCL23水平仍具有统计学显著性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c29/11627325/691910895a14/inf-44-054-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c29/11627325/691910895a14/inf-44-054-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c29/11627325/691910895a14/inf-44-054-g001.jpg

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本文引用的文献

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Nat Commun. 2024 Apr 17;15(1):3315. doi: 10.1038/s41467-024-47720-8.
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Persistent complement dysregulation with signs of thromboinflammation in active Long Covid.活动性长新冠伴有血栓炎症迹象的持续补体失调。
Science. 2024 Jan 19;383(6680):eadg7942. doi: 10.1126/science.adg7942.
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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2.
长新冠表现为 T 细胞失调、炎症和对 SARS-CoV-2 的不协调适应性免疫反应。
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Risk factors for post-COVID-19 condition (Long Covid) in children: a prospective cohort study.儿童新冠后状况（长新冠）的危险因素：一项前瞻性队列研究。
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Long COVID: major findings, mechanisms and recommendations.长新冠：主要发现、机制和建议。
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