新型冠状病毒感染后儿童的细胞因子谱：初步研究结果
Cytokine Profile in Children Following SARS-CoV-2 Infection: Preliminary Findings.
作者信息
Buonsenso Danilo, Camporesi Anna, Di Sante Gabriele, Sali Michela, Boza Maria Del Carmen Pereyra, Morello Rosa, Valentini Piero, Raffaelli Francesca, Rodriguez Lucie, Gonzalez Laura, Johnsson Anette, Mugabo Constantin Habimana, Lakshmikanth Tadepally, Brodin Petter
机构信息
From the Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Centers for Global Health Research Studies, Università Cattolica del Sacro Cuore, Rome, Italy.
出版信息
Pediatr Infect Dis J. 2025 Jan 1;44(1):54-57. doi: 10.1097/INF.0000000000004558. Epub 2024 Oct 1.
We provide preliminary evidence that, also in children, Long coronavirus disease (COVID) may be characterized by a proinflammatory signature. Ten Long COVID patients, 7 convalescent subjects after COVID infection and 4 healthy controls were enrolled. When adjusted for sex, children with long COVID had statistically significant differences in the levels of Flt3L, CD5, uPA, CCL23, CD40 and TGFα. When adjusted for age, CCL23 levels remained statistically significant.
我们提供了初步证据，表明在儿童中，长期新冠病毒病（COVID）也可能具有促炎特征。招募了10名长期新冠患者、7名新冠感染后的康复者和4名健康对照。在对性别进行调整后，长期新冠儿童在Flt3L、CD5、uPA、CCL23、CD40和TGFα水平上存在统计学显著差异。在对年龄进行调整后，CCL23水平仍具有统计学显著性。
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