Liu Fuyang, Li Kai, Zhu Qingyi
Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
Biomedicines. 2025 May 9;13(5):1145. doi: 10.3390/biomedicines13051145.
Bladder cancer, as a highly heterogeneous malignant tumor of the urinary system, is significantly affected by tumor metabolic reprogramming in its response to immunotherapy. This review systematically elaborates on the molecular mechanisms of abnormal glucose and lipid metabolism in the bladder cancer microenvironment and immune escape, and discusses precision treatment strategies based on metabolic regulation. In the future, it will be necessary to combine spatiotemporal omics and artificial intelligence technologies to construct a multi-target intervention system for the metabolic-immune interaction network, promoting a paradigm shift in precision treatment for bladder cancer.
膀胱癌作为泌尿系统一种高度异质性的恶性肿瘤，在其对免疫治疗的反应中受到肿瘤代谢重编程的显著影响。本文综述系统阐述了膀胱癌微环境中糖脂代谢异常及免疫逃逸的分子机制，并探讨了基于代谢调控的精准治疗策略。未来，有必要结合时空组学和人工智能技术，构建代谢-免疫相互作用网络的多靶点干预体系，推动膀胱癌精准治疗的模式转变。
